System Maintenance Notice

Please note that maintenance work is scheduled between 4 AM and 5 AM - CET. During this time, you may experience reduced performance. Thanks for your patience.

Publications

Journal Article Epublish

PubMed: 39925439 DOI: 10.1016/j.gmg.2024.100021

The genetic susceptibility of SOD2 gene polymorphism in sudden sensorineural hearing loss (SSNHL).

Glob Med Genet 12(1):100021

Authors: Jiahong Deng, Guifang Ma, Xianbao Cao, Yulian Chen, Lv Hu, Jinqian Zhang

Affiliations

  • Department of Otorhinolaryngology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 157, Rd. Jinbi, Kunming 650032, China.
  • College of Life Science and Technology, Kunming University of Science and Technology, No. 68, Rd. Wenchang, Kunming 650093, China.

Abstract

Background

The genic etiology of sudden sensorineural hearing loss (SSNHL) is associated with gene polymorphism which is related to oxygen metabolism of cochlear hair cells.

Objective

To investigate the genetic susceptibility of SOD2 gene polymorphism in sudden sensorineural hearing loss (SSNHL).

Method

The genotype of three tag SNPs (rs5746136, rs2842960, rs4880) variants were detected among 148 patients with SSNHL in Yunnan Province, China, and 171 matched participants without hearing loss in control group were used to screen for any risk-associated SNPs.

Result

The A/G genotype at rs5746136 locus (=1.811, 95 % =1.161-2.826,  = 0.009) was associated with susceptibility to SSNHL in Yunnan Province.

Conclusion

SOD2 gene with the rs5746136 A/G genotype is associated with an increased risk of sudden sensorineural hearing loss (SSNHL), whereas the other two tag SNPs, rs2842960 and rs4880, show no significant correlation with SSNHL. Specifically, the tag SNP rs5746136 A/G appears to be a susceptibility gene for SSNHL.

MeSH

Genes, Genetic Predisposition To Disease, Hearing, Hearing Loss, Sensorineural, Polymorphism, Genetic, Genotype, Hearing Loss