Journal Article Ppublish 5 citations
PubMed: 39931115 DOI: 10.1002/med4.86
Development of a local nomogram-based scoring system for predicting overall survival in idiopathic pulmonary fibrosis: A rural appalachian experience.
Med Adv 2(4):336-348
Authors: Rowida Mohamed, Rahul G Sangani, Khalid M Kamal, Traci J LeMaster, Toni Marie Rudisill, Virginia G Scott, George A Kelley, Sijin Wen
Affiliations
- Biological Sciences Division, University of Chicago, Chicago, Illinois, USA.
- Pulmonary and Critical Care Medicine, Northeast Georgia Health System, Gainesville, Georgia, USA.
- Department of Pharmaceutical Systems and Policy, School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA.
- Department of Epidemiology and Biostatistics, School of Public Health, West Virginia University, Morgantown, West Virginia, USA.
- School of Public and Population Health and Department of Kinesiology, Boise State University, Boise, Idaho, USA.
Abstract
Background
Accurate staging systems are essential for assessing the severity of idiopathic pulmonary fibrosis (IPF) and guiding clinical management. This study aimed to evaluate the prognostic value of pulmonary comorbidities and body mass index (BMI) in IPF, develop a nomogram predicting overall survival (OS), and create a nomogram-based survival prediction model.
Methods
Patients with IPF were identified from electronic medical records of the West Virginia hospital system. Least Absolute Shrinkage and Selection Operator (LASSO) Cox regression analysis was used for variable selection, and a nomogram was constructed. Risk groups were defined based on the nomogram's probability tertiles. The performance of the nomogram-based model was evaluated using Harrell's concordance index (C-index) and the Hosmer-Lemeshow test.
Results
The study included 152 patients with IPF. The majority of the patients were elderly, male, and had a BMI above 24 kg/m. The median survival duration was 7.6 years. The survival rates were 91% at 1 year, 78% at 3 years, and 68% at 5 years. LASSO regression selected carbon monoxide lung diffusion capacity percentage predicted (DLco%), BMI, pulmonary hypertension, pulmonary embolism, and sleep apnea as independent predictive variables. The nomogram demonstrated good discrimination (C-index = 0.71) and calibration.
Conclusions
Pulmonary comorbidities and BMI have significant prognostic value in IPF, emphasizing the necessity for consistent screening, assessment, and management of these factors in IPF care. Furthermore, the nomogram-based staging system showed promising performance in predicting OS and represents an actionable staging system that could potentially improve clinical management in IPF. Further validation of the nomogram is warranted to confirm its utility in clinical practice.
MeSH
Idiopathic Pulmonary Fibrosis, Hypertension, Comorbidity, Hypertension, Pulmonary, Body Mass Index, Fibrosis, Nomograms, Pulmonary Fibrosis