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Publications

Journal Article Multicenter Study Epublish

PubMed: 39940656 DOI: 10.3390/ijms26030886

Influence of Obstructive Sleep Apnea on Oxidative Stress in Pregnancy.

Int J Mol Sci 26(3)

Authors: Laura Cànaves-Gómez, María Paloma Giménez Carrero, Ainhoa Álvarez Ruiz De Larrinaga, Andrés Sánchez Baron, Mercedes Codina Marcet, Amanda Iglesias Coma, Mónica De-La-Peña, María Concepción Piñas Cebrian, Susana García Fernández, José Antonio Peña Zarza, Daniel Morell-Garcia, Antonia Barceló Bennasar, Alberto Alonso-Fernández

Affiliations

  • Institut d'Investigació Sanitària Illes Balears (IdISBa), 07120 Palma de Mallorca, Spain.
  • Sleep Unit, Hospital Universitario de Araba, 01009 Vitoria, Spain. Instituto de Investigación BIOARABA, 01009 Vitoria, Spain.
  • Servicio de Neumología, Hospital Universitario Miguel Servet, 50009 Zaragoza, Spain.
  • Department of Endocrinology and Metabolism, Hospital Universitario Son Espases, 07120 Palma de Mallorca, Spain.
  • Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.
  • Department of Pneumology, Hospital Universitario Son Espases, 07120 Palma de Mallorca, Spain.
  • Facultad de Medicina, Universidad de las Islas Baleares, 07120 Palma de Mallorca, Spain.
  • Institut d'Investigació Sanitària Illes Balears (IdISBa), 07120 Palma de Mallorca, Spain. Department of Pneumology, Hospital Universitario Son Espases, 07120 Palma de Mallorca, Spain.
  • Department of Pediatrics, Hospital Universitario Son Espases, 07120 Palma de Mallorca, Spain.
  • Department of Clinical Analysis, Hospital Universitario Son Espases, 07120 Palma de Mallorca, Spain.

Abstract

Obstructive sleep apnea (OSA) is common during pregnancy and linked to adverse outcomes. While oxidative stress is a proposed pathogenic mechanism, evidence in pregnant populations remains limited. This multicenter, prospective study evaluated oxidative stress through protein carbonyl levels in 171 pregnant women and 86 cord blood samples. Polysomnography (PSG) performed during pregnancy categorized participants with the apnea-hypopnea index (AHI) in OSA, rapid eye movement (REM) OSA, and supine OSA. Protein carbonyl levels were measured by the dinitrophenyl hydrazine (DNPH) method. No significant differences were found in maternal or cord blood protein carbonyl levels between OSA and non-OSA groups, or between REM and supine OSA subgroups. Interestingly, women with shorter apnea-hypopnea (AH) length showed both higher maternal and cord blood protein carbonyl levels and lower nocturnal oxygen saturation. Overall, OSA in pregnancy was not associated with increased oxidative stress as measured by protein carbonyl levels. However, apnea-hypopnea duration and nocturnal hypoxia may influence oxidative stress, pointing to a complex relationship between OSA and oxidative stress during pregnancy, beyond traditional metrics like AHI. Future studies should explore additional biomarkers and diverse molecular pathways that could play a role, with special attention to emerging factors such as apnea-hypopnea length and hypoxic burden to elucidate the interrelationships between OSA and pregnancy more comprehensively.

MeSH

Pregnancy, Blood, Sleep Apnea, Obstructive, Sleep, Stress, Physiological, Apnea, Oxidative Stress, Sleep Apnea Syndromes, Blood Proteins