Journal Article Ppublish
PubMed: 39945028 DOI: 10.1177/10760296251317520
Prognostic Nutritional Index as a Potential Biomarker for the Risk of Lower Extremity Deep Venous Thrombosis: A Large Retrospective Study.
Clin Appl Thromb Hemost 31:10760296251317520
Authors: Hong Wang, Qing Zhou, Zhicong Wang, Xi Chen, Yuxuan Wu, Mozhen Liu
Affiliations
- Department of Orthopedics, People's Hospital of Deyang City, Deyang, China.
- Department of Orthopedics, People's Hospital of Deyang City, Deyang, China. Department of Orthopedics, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
- Department of Orthopedics, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Abstract
BACKGROUND
Prognostic nutritional index (PNI) has recently been identified as a novel marker of nutritional status. However, existing evidences on the association between PNI and the risk of lower extremity deep venous thrombosis (LEDVT) are limited and conflicting.
OBJECTIVE
To determine the association between PNI and the risk of LEDVT, and further evaluate its diagnostic value.
METHODS
Over a 10-year period (2012-2022), a total of 12790 patients who underwent compression ultrasonography examinations were consecutively included, and 1519 (11.9%) LEDVT events occurred. Multivariate logistic regression analysis was used to investigate the association, and receiver operating characteristic (ROC) curve was constructed to evaluate its diagnostic performance.
RESULTS
After full adjustment, patients in third quartile (odds ratio [OR] = 1.486, 95% confidence interval [CI]: 1.205-1.832), second quartile (OR = 2.436, 95% CI: 1.993-2.978) and first quartile (OR = 3.422, 95% CI: 2.791-4.195) of PNI were at higher risk of LEDVT compared with those in fourth quartile, and the test for trend was significant. Consistently, each unit decrease in PNI was associated with a 6.0 % (95% CI: 1.052-1.069) increased risk of LEDVT. Moreover, adding PNI to a base model improved the area under the curve (AUC) from 0.721 (95% CI: 0.709-0.734) to 0.746 (95% CI: 0.734-0.758).
CONCLUSION
PNI is inversely associated with the risk of LEDVT, and provides significant incremental diagnostic value for the identification of LEDVT events. These findings suggest that PNI may be a potential biomarker to help clinicians identify patients at risk of thrombosis and make clinical decisions timely.
MeSH
Retrospective Studies, Venous Thrombosis, Biomarkers, Thrombosis, Hemostasis