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Publications

Journal Article Observational Study Epublish

PubMed: 39965871 DOI: 10.1136/bmjdrc-2024-004727

Alterations of hepatic lipid content following COVID-19 in persons with type 2 diabetes.

BMJ Open Diabetes Res Care 13(1)

Authors: Yuliya Kupriyanova, Iryna Yurchenko, Pavel Bobrov, Frederik Bartels, Stefan Wierichs, Marc Jonuscheit, Benedict Korzekwa, Katsiaryna Prystupa, Martin Schön, Dania Mendez, Sandra Trenkamp, Volker Burkart, Robert Wagner, Vera Schrauwen-Hinderling, Michael Roden

Affiliations

  • Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
  • German Center for Diabetes Research (DZD), Partner Düsseldorf, Neuherberg, Germany.
  • Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
  • Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany. German Center for Diabetes Research (DZD), Partner Düsseldorf, Neuherberg, Germany.
  • Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany. German Center for Diabetes Research (DZD), Partner Düsseldorf, Neuherberg, Germany. Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
  • Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands.
  • Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
  • Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Abstract

INTRODUCTION

The study aimed to assess the effect of COVID-19 on hepatic lipid (HL) content, fibrosis risk, and adiposity in persons with type 2 diabetes.

RESEARCH DESIGN AND METHODS

Participants with type 2 diabetes with a history of mild COVID-19 (n=15, age 58±12 years, body mass index 30.9±5.2 kg/m 2) were examined before (baseline) and 1 year (12±2 months) after (follow-up) recovery from COVID-19. Investigations for changes in metabolic risk comprised clinical examination, fasting blood sampling and MR-based measurements. Potential changes were corrected with the time course of the respective parameters in a group of participants who did not contract COVID-19 over the same time course (n=14, 61±6 years, 30.0±4.6 kg/m 2).

RESULTS

COVID-19 resulted in a relative increase in HL content of 56% (95% CI 18%, 106%; p=0.04) measured as proton density fat fraction (HL-PDFF), corrected for the time course in the absence of COVID-19. While no changes in hepatic stiffness and volume, intramyocellular lipids, whole-body, subcutaneous and visceral adipose tissue volumes as well as homeostatic model assessment of insulin resistance and beta-cell function were observed.

CONCLUSIONS

History of COVID-19 in persons with type 2 diabetes is associated with higher HL-PDFF after 1 year following recovery from infection.

TRIAL REGISTRATION NUMBER

NCT01055093.

MeSH

Diabetes Mellitus, Cells, Recycling, Covid-19, Diabetes Mellitus, Type 2