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Publications

Journal Article Epublish

PubMed: 39974178 DOI: 10.1093/braincomms/fcaf060

and CAG triplet repeat sizes: exploring their role in the disease risk and cancer comorbidity in Parkinson's disease.

Brain Commun 7(1):fcaf060

Authors: Sergio Pérez-Oliveira, Ignacio Álvarez, Manuel Menéndez-González, Israel David Duarte-Herrera, Marta Blázquez-Estrada, Juan Castilla-Silgado, Esther Suárez, Ciara García-Fernández, Pablo Siso-García, Pablo García-González, Maitee Rosende-Roca, Mercè Boada, Agustín Ruiz, Jon Infante, Beatriz De la Casa-Fages, Isabel González-Aramburu, Victoria Álvarez, Pau Pastor

Affiliations

  • Laboratorio de Genética, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain. Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain.
  • Department of Neurology, Movement Disorders Unit, University Hospital Mútua de Terrassa and Fundació Docència i Recerca Mútua de Terrassa, 08221 Terrassa, Barcelona, Spain.
  • Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain.
  • Servicio de Neurología, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.
  • Departamento de Medicina, Universidad de Oviedo, 33006 Oviedo, Spain.
  • Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain. Networked Biomedical Research Center (CIBER)-Respiratory Diseases, 28029 Madrid, Spain.
  • Asociación Parkinson Asturias (APARKAS), 33011 Oviedo, Spain.
  • Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain. Servicio de Neurología, Hospital Universitario de Cabueñes, 33394 Gijón, Spain.
  • Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08028 Barcelona, Spain.
  • Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain.
  • Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08028 Barcelona, Spain. Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain.
  • Department of Neurology, Marqués de Valdecilla University Hospital, Universidad de Cantabria, 39008 Santander, Spain.
  • Department of Neurology, Movement Disorders Unit, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.
  • Instituto Investigación Sanitaria Gregorio Marañón, 28007 Madrid, Spain.
  • Laboratorio de Genética, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.
  • Department of Neurology, Unit of Neurodegenerative diseases, University Hospital Germans Trias i Pujol and The Germans Trias i Pujol Research Institute (IGTP) Badalona, 08916 Barcelona, Spain.

Abstract

Parkinson's disease genetic embraces genetic and non-genetic factors. It has been suggested a link between CAG repeat number in the and genes and different neurodegenerative diseases. Several genetic factors involved in Parkinson's disease development are indeed associated with cancer pathways. Moreover, several studies found a low prevalence of cancer in neurodegenerative diseases that can be associated with a low CAG repeat size in several genes. This study aimed to investigate the influence of CAG repeat sizes in and genes on the risk for developing cancer and Parkinson's disease in a large cohort of patients with idiopathic Parkinson's disease and healthy controls. The work included 1052 patients with idiopathic Parkinson's disease and 1070 controls of European ancestry. CAG repeat sizes in and 2 genes were analysed. Dunn's multiple comparison test for quantitative variables and logistic and linear regression were used. The long and alleles and CAG size and both the short and long alleles were predictors for the Parkinson's disease risk. The long CAG allele gene was associated with the risk of cancer. No association was observed between CAG size in the and genes and risk of cancer in patients with Parkinson's disease. We described an association of and with the risk of Parkinson's disease, which reinforce the hypothesis of the common pathway of neurodegeneration. Besides, could be a predictor of cancer risk among patients with Parkinson's disease, and these results suggest that cancer and neurodegeneration processes can share common pathways.

MeSH

Genes, Comorbidity, Parkinson Disease, Neoplasms, Trinucleotide Repeats, Alleles, Neurodegenerative Diseases