Journal Article Review Epublish 4 citations
PubMed: 40003711 DOI: 10.3390/life15020302
Sperm Separation and Selection Techniques to Mitigate Sperm DNA Damage.
Life (Basel) 15(2)
Authors: Steven Fleming, David Morroll, Martine Nijs
Affiliations
- Discipline of Anatomy & Histology, School of Medical Sciences, University of Sydney, Sydney, NSW 2000, Australia.
- CooperSurgical, 2750 Ballerup, Denmark.
Abstract
Semen preparation and sperm selection techniques exploit the morphological and physiological characteristics of sperm function, including motility, morphology, density, and maturity, as reflected by their cell-surface charge and the expression of hyaluronan receptors. The various methods employed have a common purpose of mimicing sperm selection within the female reproductive tract and, thereby, increasing the likelihood that oocytes will be fertilised by spermatozoa with intact nuclear DNA and a normal genome. Indeed, the paternal genome is relevant to embryonic genome activation and blastocyst development, and has a fundamental impact upon successful implantation, ongoing pregnancy and live birth. The clinical use of both well-established and some more recently developed techniques is discussed in this comparative clinical review of sperm separation from seminal plasma and selection for insemination.
MeSH
Genome, Spermatozoa, Dna, Dna Damage