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Journal Article Review Epublish 2 citations

PubMed: 40004157 DOI: 10.3390/ijms26041693

The Potential of Superoxide Dismutase-Rich as a Promoter of Cellular Health.

Int J Mol Sci 26(4)

Authors: Stuart P Cocksedge, Lalia Mantecón, Enrique Castaño, Carlos Infante, Stephen J Bailey

Affiliations

  • School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK.
  • Centre for Physical Activity, Sport and Exercise Sciences, Coventry University, Coventry CV1 5FB, UK.
  • Fitoplancton Marino, S.L. Dársena Comercial s/n, 11500 El Puerto de Santa María, Cádiz, Spain.

Abstract

() is a green, marine, eukaryotic, microalgae that was authorized in the European Union (EU) as a novel food for human consumption in 2014, and as a food supplement in 2017. This narrative review will provide an overview of preclinical and clinical trials assessing the efficacy of a -derived ingredient, characterized by a high superoxide dismutase (SOD) activity (SOD-rich ), to improve various aspects of cellular health. Collectively, results from in vitro, and more importantly in vivo research, support SOD-rich as a potential promoter of cellular health. Principally, the ingredient appears to function as an indirect antioxidant by boosting intracellular antioxidant systems. Moreover, it can positively modulate inflammatory status by up-regulating anti-inflammatory and down-regulating pro-inflammatory cytokines and factors. In addition, SOD-rich appears to promote cellular health though protecting from DNA damage, boosting immune function, strengthening cell structure and integrity, and positively modulating cell signaling pathways. There is also some evidence to suggest that SOD-rich may improve aspects of mitochondrial function through the up-regulation of genes linked to mitochondrial biogenesis and ATP synthesis. From the trials conducted to date, transcriptional activation of nuclear factor erythroid 2-related factor 2 (NRF2) and sirtuin 1 (SIRT1) appear to be important in mediating the effects of SOD-rich on cellular health. These exciting preliminary observations suggest that SOD-rich may represent a natural blue food supplement with the potential to enhance various aspects of cellular health.

MeSH

Cells, Genes, Promoter Regions, Genetic, Dietary Supplements, Food, Antioxidants, Superoxides, Superoxide Dismutase, Sirtuin 1

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