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Journal Article Review Epublish 1 citation

PubMed: 40004246 DOI: 10.3390/ijms26041783

Metformin's Effects on Cognitive Function from a Biovariance Perspective: A Narrative Review.

Int J Mol Sci 26(4)

Authors: Dimitrie Chele, Carmen-Adella Sirbu, Marian Mitrica, Mihai Toma, Octavian Vasiliu, Anca-Maria Sirbu, Francois Jerome Authier, Dan Mischianu, Alice Elena Munteanu

Affiliations

  • Department of Neurology, Elias Emergency University Hospital, 011461 Bucharest, Romania.
  • Clinical Neurosciences Department, University of Medicine and Pharmacy "Carol Davila" Bucharest, 050474 Bucharest, Romania.
  • Academy of Romanian Scientists, 050045 Bucharest, Romania.
  • Department of Medical-Surgical and Prophylactical Disciplines, Faculty of Medicine, 'Titu Maiorescu' University, 031593 Bucharest, Romania.
  • Department of Psychiatry, 'Dr. Carol Davila' Central Military Emergency University Hospital, 010825 Bucharest, Romania.
  • National Institute of Medical Expertise and Recovery of Work Capacity, Panduri 22, 050659 Bucharest, Romania.
  • Neuromuscular Reference Center, Henri Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, 94000 Créteil, France.
  • INSERM U955-Team Relaix, Faculty of Health, Paris Est-Creteil University, 94010 Créteil, France.
  • Department No. 3, University of Medicine and Pharmacy "Carol Davila" Bucharest, 050474 Bucharest, Romania.

Abstract

This study examines the effects of metformin on brain functions focusing on the variability of the results reported in the literature. While some studies suggest that metformin may have neuroprotective effects in diabetic patients, others report an insignificant impact of metformin on cognitive function, or even a negative effect. We propose that this inconsistency may be due to intrinsic cellular-level variability among individuals, which we term "biovariance". Biovariance persists even in demographically homogeneous samples due to complex and stochastic biological processes. Additionally, the complex metabolic actions of metformin, including its influence on neuroenergetics and neuronal survival, may produce different effects depending on individual metabolic characteristics.

MeSH

Diabetes Mellitus, Neuroprotection, Cognition, Metformin

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