Journal Article Ppublish
PubMed: 40008451 DOI: 10.1021/acs.biomac.4c01738
One-Step Synthesis of Poly(2-alkyl-2-oxazoline)-Coated Gold Nanospheres: A Greener Approach for Biomedical Uses.
Biomacromolecules 26(3):1923-1934
Authors: Léa Daoud, Stéphane Hoang, Alexia Milin-Moguerou, Joël Eyer, Tony Breton, Véronique Montembault, Laurent Fontaine, Catherine Passirani, Patrick Saulnier, Oksana Krupka
Affiliations
- Univ Angers, Inserm, CNRS, MINT, SFR ICAT, F-49000 Angers, France.
- Univ Angers, CNRS, MOLTECH-Anjou, SFR MATRIX, F-49000 Angers, France.
- Institut des Molécules et Matériaux du Mans, UMR 6283 CNRS-Le Mans Université, Le Mans 72085, France.
Abstract
The biological application of gold nanospheres (AuNSs) is often constrained by their stability and cytotoxicity. We present a greener synthetic approach that gives a simple and more environmentally friendly route to synthesizing AuNSs for biomedical applications. In this study, we detail a novel one-step, green synthesis of poly(2-alkyl-2-oxazoline) (POx)-coated AuNSs, which eliminates the need for additional reducing and stabilizing agents. The impact of the polymer structure on the nanoparticle formulation kinetics and nanoparticle characteristics is thoroughly investigated, revealing that the terminal functional group and the alkyl side chain significantly influence the reduction and stabilization process of AuNSs. Finally, POx-coated AuNSs were tested in vitro against F98 glioblastoma cells and proved to be usable without significant toxicity up to 75 μM. Herein, the outlined rapid and efficient method of the preparation of POx-coated AuNSs serves as a foundation for advancing the development of complex AuNSs tailored for biomedical applications.
MeSH
Polymers, Biological Science Disciplines, Nanoparticles, Nanospheres