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Publications

Journal Article Systematic Review Epublish

PubMed: 40012999 DOI: 10.3389/fneur.2025.1499493

Role of microRNA in the risk stratification of ischemic strokes.

Front Neurol 16:1499493

Authors: Hosam M Al-Jehani, Ahmed Hafez Mousa, May Adel Alhamid, Fawaz Al-Mufti

Affiliations

  • Department of Neurosurgery and Interventional Neuroradiology and Critical Care Medicine, Imam Abdulrahman Bin Faisal University, Al Khobar, Saudi Arabia. Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada. Department of Neurosurgery, Houston Methodist Hospital, Weill Cornell University, Houston, TX, United States. Department of Neurosurgery and Interventional Neuroradiology, King Fahd Hospital Specialist Hospital, Dammam, Saudi Arabia.
  • Department of Neurosurgery and Interventional Neuroradiology, King Fahd Hospital Specialist Hospital, Dammam, Saudi Arabia.
  • Neurosciences, Dubai Health, Dubai, United Arab Emirates.
  • Department of Neurosurgery, Graduate Medical Education, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
  • Department of Neurosurgery and Interventional Neuroradiology, Imam Abdulrahman Bin Faisal University, Al Khobar, Saudi Arabia.
  • Department of Neurology and Interventional Neuroradiology, King Fahad Hospital of the University, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
  • Department of Neurology and Neurosurgery, Westchester Medical Center at New York Medical College, Valhalla, NY, United States.

Abstract

Background

Ischemic stroke is a major cause of death and morbidity, and risk classification is essential for predicting therapeutic outcomes. MicroRNAs may be useful indicators for risk stratification, as they control gene expression and influence physiological and pathological processes.

Methodology

A systematic strategy was developed to search relevant material using databases like PubMed, Scopus, and Web of Science. Selection criteria included human research, a certain date, or categories of studies. Data extraction, synthesis, and analysis were carried out to find trends, similarities, and differences among the chosen studies. The study's design, sample size, methodology, statistical analysis, and any potential biases or restrictions from the selected reference papers were also taken into account.

Results and findings

MicroRNA is an important biomarker for risk stratification in Ischemic Strokes. It can be used to identify Stroke-Specific microRNA Signatures, identify diagnostic and prognostic values, and regulate Vascular Inflammation, Endothelial Dysfunction, and Thrombus Formation and Resolution. It also has potential therapeutic applications.

Conclusion

MicroRNAs have emerged as promising biomarkers for predicting stroke risk, severity of strokes, and clinical outcomes. They can be used to predict the severity of a stroke and aid clinicians in making treatment decisions.

MeSH

Ischemic Stroke, Stroke, Micrornas, Biomarkers, Therapeutics

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