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Publications

Journal Article Epublish

PubMed: 40013277 DOI: 10.5455/javar.2024.k844

Effects of edible bird's nest and EDTA on cadmium toxicity exposed rats' embryo production, quality, and pre- and post-embryo transfer pregnancy rates.

J Adv Vet Anim Res 11(4):944-953

Authors: Anmar Jasim Mohammed, Nurhusien Yimer, Faez Firdaus Abdullah Jesse, Wan Nor Fitri Wan Jaafar, Ainu Husna

Affiliations

  • Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, University Putra Malaysia, Seri Kembangan, Malaysia. College of Veterinary Medicine, University of Fallujah, Fallujah, 31002, Iraq.
  • Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, University Putra Malaysia, Seri Kembangan, Malaysia.
  • Department of Veterinary Sciences, School of Medicine, International Medical University, Kuala Lumpur, Malaysia.
  • Division of Veterinary Reproduction, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.
  • Farm and Exotic Animal Medicine and Surgery, Faculty of Veterinary Medicine, University Putra Serdang, Seri Kembangan, Malaysia.
  • Livestock Science Division, Malaysian Agricultural Research Institute, Serdang, Selangor 43400, Malaysia.

Abstract

Objectives

The current study aimed to investigate the prophylactic potential of EBN compared to EDTA in mitigating Cd's toxic effects on pregnancy rates and embryonic development in rats.

Materials and Methods

Ninety-eight female rats (Sprague Dawley) were divided into donor and recipient groups, with donors further divided into seven subgroups, including negative control, Cd-exposed, EBN-treated, and EDTA-treated groups. Embryos from donors were transferred to recipient rats, with EBN and Cd administered for 4 weeks and EDTA given only in the last 5 days for the donor group.

Results

Results showed significant differences in pregnancy rates and blastocyst quality. EBN at 120 mg/kg BW led to higher blastocyst production and better quality compared to Cd-exposed groups. The highest pregnancy rates in recipient groups correlated with the highest blastocyst scores from donors.

Conclusion

EBN at 120 mg/kg demonstrated significant protection against Cd toxicity and its effect on pregnancy rates, embryo production, quality, and pre- and post-embryo transfer, surpassing the effects of both 90 mg/kg EBN and EDTA. This study provides empirical evidence in support of the conventional belief in the positive impact of EBN on female reproduction.

MeSH

Blastocyst, Pregnancy, Embryo Transfer, Edetic Acid, Pregnancy Rate