Journal Article Review Ppublish
PubMed: 40020873 DOI: 10.1016/j.pharma.2025.02.010
Photodynamic anti-cancer therapy and arachidonic acid metabolism: State of the art in 2024.
Ann Pharm Fr 83(5):785-795
Authors: Hicham Wahnou, Youness Limami, Raphaël Emmanuel Duval, Bassel Ismail, David Yannick Léger, Vincent Sol, Bertrand Liagre
Affiliations
- Laboratory of Immunology and Biodiversity, Faculty of Sciences Ain Chock, Hassan II University, BP2693 Maarif, Casablanca, Morocco.
- Sciences and Engineering of Biomedicals, Biophysics and Health Laboratory, Higher Institute of Health Sciences, Hassan First University, Settat, Morocco.
- Université de Lorraine, 54000 Nancy, France.
- College of Health and Medical Technology, Medical Laboratories Technology Department, Alayen Iraqi University, Thi-Qar 64001, Iraq.
- Université de Limoges, LABCiS UR 22722, faculté de Pharmacie, 87000 Limoges, France.
- Université de Limoges, LABCiS UR 22722, faculté de Pharmacie, 87000 Limoges, France.
- Université de Limoges, LABCiS UR 22722, faculté de Pharmacie, 87000 Limoges, France.
Abstract
Photodynamic therapy (PDT) has emerged as a promising and evolving modality in cancer treatment leveraging light-sensitive compounds known as photosensitizers to selectively induce cell death in malignant tissues through the generation of reactive oxygen species (ROS). This review delves into the intricate mechanisms of PDT highlighting the pivotal role of photosensitizers and the resultant oxidative stress that damages cancer cells. It explores the versatile applications of PDT across various cancer types alongside the advantages and limitations inherent to this therapy. Recent technological advancements including improved photosensitizers and novel light delivery systems are also discussed. Additionally the review examines the critical role of arachidonic acid (AA) metabolism in cancer progression detailing the cyclooxygenase, lipoxygenase and cytochrome P450 pathways and their contributions to tumor biology. By elucidating the interplay between PDT and AA metabolism the review underscores the potential of targeting AA metabolic pathways to enhance PDT efficacy. Finally it provides clinical and translational perspectives highlighting ongoing research and future directions aimed at optimizing PDT for improved cancer treatment outcomes.
MeSH
Cells, Arachidonic Acid, Neoplasms, Photosensitizing Agents, Pharmacology, Therapeutics