Journal Article Review Ppublish
PubMed: 40025880 DOI: 10.1080/17501911.2025.2473309
Epigenomic mechanisms of dietary prescriptions for obesity therapy.
Epigenomics 17(6):423-434
Authors: Omar Ramos-Lopez
Affiliations
- Medicine and Psychology School, Autonomous University of Baja California, Tijuana, Baja California, Mexico.
Abstract
Dietary modification is a cornerstone and a primary goal for weight loss, whose effects may be related to epigenetic phenomena. In this literature review, a comprehensive search without time restriction was performed in PubMed/Medline, Cochrane, SciELO, and Scopus databases to identify epigenetic signatures related to obesity outcomes upon dietary advice. In this context, experimental studies and clinical trials have identified certain DNA methylation marks, miRNA expression profiles and histone modifications putatively associated with adiposity outcomes after different nutritional interventions. These include traditional dietary patterns, diets with different macronutrient compositions, and supplementation with fatty acids, amino acids and derivatives, methyl donors, vitamins and minerals, probiotics and prebiotics, and bioactive food compounds. Some of these epigenetic signatures have been mapped to genes involved in food intake control, adipogenesis, lipolysis, fatty acid oxidation, body fat deposition, and gut microbiota modulation. However, additional studies are still required to address dosage and follow-up variability, validation of epigenetic marks, genome-wide approaches, and appropriate statistical settings. Although more investigation is required, these insights may contribute to the characterization of epigenetic biomarkers of body weight regulation toward the prescription of tailored dietary strategies targeting the epigenome for a more precise obesity management and control.
MeSH
Genes, Epigenomics, Amino Acids, Genome, Prescriptions, Food, Obesity, Therapeutics, Histone Code, Fatty Acids