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Publications

Journal Article Systematic Review Meta-Analysis Epublish

PubMed: 40028331 DOI: 10.3389/fimmu.2025.1450798

Serum surfactant protein D as a significant biomarker for predicting occurrence, progression, acute exacerbation, and mortality in interstitial lung disease: a systematic review and meta-analysis.

Front Immunol 16:1450798

Authors: Xing He, Jiaqi Ji, Dan Zheng, Zeli Luo, Linjie Luo, Lu Guo

Affiliations

  • Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China. State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Department of Pulmonary and Critical Care Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
  • Department of Critical Care Medicine, Wenjiang District People's Hospital of Chengdu, Chengdu, China.

Abstract

Objective

Serum surfactant protein D (SP-D) is a potential biomarker for the non-invasive prediction of interstitial lung disease (ILD) status. However, previous studies lacked comprehensively qualitative and quantitative pooled analysis methods to summarize the relationship between SP-D and ILD.

Methods

We conducted a comprehensive literature search from PubMed, Embase, Web of Science, Scopus, Ovid, and Cochrane Library, up to 16 December 2023. The Newcastle-Ottawa Quality Assessment Scale was employed to evaluate the quality of each included study. Pooled analyses were primarily performed for weighted mean difference (WMD), odds ratio (OR), and hazard ratio (HR). Sensitivity analysis was conducted by sequentially eliminating one study at a time and reanalyzing the remaining studies. In addition, the trim-and-fill method was applied for correcting publication bias.

Results

More than 3,561 patients with ILD from 41 articles were included for pooled analysis. The pooled results showed that serum SP-D levels were higher in the ILD group than the control group (WMD = 120.24 ng/mL, 95% CI: 72.45-168.03, p<0.001). Additionally, SP-D levels among patients with ILD were significantly elevated in the acute exacerbation (AE) group compared with the non-AE group (WMD = 9.88 ng/mL, 95% CI: 2.64-17.12, p=0.008), and in the death group compared with the survival group (WMD = 32.98 ng/mL, 95% CI: 2.11-63.84, p=0.036). However, no significant difference was observed between the progression group and the stable group (WMD = 13.54 ng/mL, 95% CI: -23.68-50.76, p=0.227). In addition, pooled results demonstrated that serum SP-D was a reliable predictive factor for various outcomes associated with ILD: occurrence (OR=4.66, 95%CI = 2.46, 8.86, p<0.001), progression (OR=1.003, 95%CI= 1.001, 1.006, p=0.033), and mortality (HR=1.002, 95%CI= 1.001, 1.003, p=0.023) of ILD. In contrast, there was no significant difference for predicting AE (HR = 1.004, 95% CI = 0.997, 1.011, p=0.240).

Conclusion

Serum SP-D is a significant biomarker associated with ILD occurrence, progression, acute exacerbation, and mortality. It remains essential to clarify the predictive value of serum SP-D levels concerning the disease status in patients with different ILD subtypes. Moreover, it may be beneficial to conduct a combined analysis of SP-D with other potential biomarkers to further enhance its diagnostic capability regarding the disease status in patients with ILD.

Systematic Review Registration

https://inplasy.com/inplasy-2024-5-0050/, identifier INPLASY 202450050.

MeSH

Mortality, Lung, Serum, Biomarkers, Immune System Diseases, Lung Diseases, Pulmonary Surfactant-Associated Protein D, Lung Diseases, Interstitial