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Publications

Journal Article Epublish

PubMed: 40032933 DOI: 10.1038/s41598-025-91965-2

Metabolomic and lipoproteomic differences and similarities between COVID-19 and other types of pneumonia.

Sci Rep 15(1):7507

Authors: Veronica Ghini, Valentina Pecchioli, Tommaso Celli, Nunzia Boccia, Laura Bertini, Francesca Veneziani, Vieri Vannucchi, Paola Turano

Affiliations

  • Department of Chemistry "Ugo Schiff", University of Florence, Sesto Fiorentino, FI, Italy.
  • Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (CIRMMP), Sesto Fiorentino, FI, Italy.
  • Internal Medicine, USL Toscana Centro, Santa Maria Nuova Hospital, Florence, Italy.
  • Laboratory of Clinical Pathology, USL Toscana Centro, Santa Maria Nuova Hospital, Florence, Italy.
  • Department of Chemistry "Ugo Schiff", University of Florence, Sesto Fiorentino, FI, Italy.
  • CERM, University of Florence, Sesto Fiorentino, FI, Italy.

Abstract

COVID-19 infection has revealed significant effects on the human blood metabolome and lipoproteome, which have been coherently observed in different cohorts worldwide and across the various waves of SARS-CoV-2 pandemic. As one of the main clinical manifestations of COVID-19 is a severe acute respiratory illness, it is pertinent to explore whether this metabolic/lipoproteomic disturbance is associated with the respiratory symptoms. To this purpose we are here reporting comparativeH NMR analyses of the plasma of 252 COVID-19 patients and of patients with non-COVID-19 interstitial (24 individuals) or lobar (21 individuals) pneumonia, all matched by age, gender and disease severity. The analysis is based on 24 metabolites and 114 lipoprotein parameters. Several common traits are observed among the three groups, albeit with some peculiar features characteristic of each group. The main differences were observed between the lobar cases and all the others.

MeSH

Covid-19, Pneumonia, Metabolomics, Natural Science Disciplines

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