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Publications

Journal Article Review Epublish

PubMed: 40033423 DOI: 10.1186/s12987-025-00632-1

Research priorities for non-invasive therapies to improve hydrocephalus outcomes.

Fluids Barriers CNS 22(1):24

Authors: Alexandra Hochstetler, Christine Hehnly, William Dawes, Daniel Harris, Cameron Sadegh, Francesco T Mangano, Samantha N Lanjewar, Monica J Chau

Affiliations

  • Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
  • Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
  • Department of Paediatric Neurosurgery, Oxford University Hospital, Oxford, UK.
  • Amazon.Com, Inc, Seattle, WA, 98109, USA.
  • Department of Neurosurgery, University of California-Davis, Sacramento, CA, 95817, USA.
  • Division of Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
  • Research Department, Hydrocephalus Association, Bethesda, MD, 20814, USA.
  • Research Department, Hydrocephalus Association, Bethesda, MD, 20814, USA.

Abstract

The Hydrocephalus Association organized two workshops with the support of the Rudi Schulte Research Institute and Cincinnati Children's Hospital Medical Center entitled "Developing Non-Invasive Hydrocephalus Therapies: Molecular and Cellular Targets", held September 27-29, 2023, in Dallas, TX, and "Developing Non-Invasive Hydrocephalus Therapies: Advancing Towards Clinical Trials", held April 12-13, 2024, in Cincinnati, OH. The goal of these workshops was to explore the frontiers of ongoing research for non-invasive therapies for the treatment of hydrocephalus across all etiologies and to improve patient outcomes at all stages of diagnosis and management. During the consensus-building discussions throughout the research workshops, basic, translational, and clinical scientists aimed to identify the next steps to develop novel treatments for hydrocephalus. This detailed report discusses the research priorities that emerged from these workshops to inspire researchers and guide studies towards better treatment for people living with hydrocephalus.

MeSH

Research, Therapeutics, Hydrocephalus

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