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Publications

Journal Article Ppublish

PubMed: 40033812 DOI: 10.1021/jacs.4c16367

Noninvasive Vagus Nerve Electrical Stimulation for Immune Modulation in Sepsis Therapy.

J Am Chem Soc 147(10):8406-8421

Authors: Cam-Hoa Mac, Giang Le Thi Nguyen, Dien Thi My Nguyen, Sheng-Min Huang, Hsu-Hsia Peng, Yen Chang, Shih-Kai Lo, Hui-Hua Kenny Chiang, Yuan-Zhen Yang, Hsiang-Lin Song, Wei-Tso Chia, Yu-Jung Lin, Hsing-Wen Sung

Affiliations

  • Department of Chemical Engineering, National Tsing Hua University, Hsinchu 300044, Taiwan.
  • Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan.
  • Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300044, Taiwan.
  • Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and School of Medicine, Tzu Chi University, Hualien 970473, Taiwan.
  • Institute of Biomedical Engineering, National Yang-Ming Chiao Tung University, Taipei 112304, Taiwan.
  • Department of Pathology, National Taiwan University Hospital, Hsinchu Branch, Hsinchu 302058, Taiwan.
  • Department of Orthopedics, National Taiwan University Hospital, Hsinchu Branch, Hsinchu 302058, Taiwan.
  • Research Center for Applied Sciences, Academia Sinica, Taipei 115201, Taiwan.

Abstract

Sepsis presents a significant medical challenge due to its intense inflammatory response to infection, often resulting in high mortality rates. A promising therapeutic strategy targets the cholinergic anti-inflammatory pathway (CAIP), which regulates immune responses. This study investigates the ingestion of piezoelectric particles that adhere to the stomach lining, specifically targeting TRPV1 receptors. In a mouse model of sepsis, these particles, when activated by low-intensity pulsed ultrasound, generate mild electrical pulses. These pulses stimulate vagal afferent fibers, transmitting signals to the brain and modulating the neural-immune network via the CAIP. Consequently, this leads to a reduction in systemic inflammation, mitigating weight loss, alleviating multiple tissue injuries, and preventing death by modulating immune cells in the spleen. This approach addresses the critical need for noninvasive sepsis therapies, potentially improving patient outcomes. Utilizing portable ultrasound equipment with minimal thermal effects, this technique offers a safe and convenient treatment option, even for home use.

MeSH

Sepsis, Vagus Nerve, Therapeutics, Pulse

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