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Publications

Journal Article Ahead of print

PubMed: 40036593 DOI: 10.1093/cid/ciaf092

Effects of the COVID-19 pandemic on TB outcomes in the United States: a Bayesian analysis.

Clin Infect Dis

Authors: Nicole A Swartwood, Ted Cohen, Suzanne M Marks, Andrew N Hill, Garrett R Beeler Asay, Julie Self, Pei-Jean I Feng, C Robert Horsburgh, Joshua A Salomon, Nicolas A Menzies

Affiliations

  • Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
  • Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Boston University Schools of Public Health and Medicine, Departments of Epidemiology, Biostatistics, Global Health and Medicine, Boston, MA, USA.
  • Department of Health Policy, Stanford University School of Medicine, Stanford, CA, USA.

Abstract

BACKGROUND

Tuberculosis (TB) notifications and deaths in the United States fluctuated substantially during the COVID-19 pandemic. We analyzed multiple data sources to understand the factors contributing to these changes and estimated future TB trends.

METHODS

We identified four mechanisms potentially contributing to observed TB trends during 2020-2023: immigration, respiratory contact rates, rates of accurate diagnosis and treatment initiation, and mortality rates for persons experiencing TB disease. We employed a Bayesian approach to synthesize evidence on how these mechanisms changed during the pandemic and how they might have combined to produce observed 2020-2023 TB data, using a transmission-dynamic model to link mechanisms to TB outcomes. We also simulated a no-pandemic-counterfactual scenario that assumed mechanisms followed pre-pandemic trends. We estimated TB outcomes associated with the pandemic until 2035 to capture lagged effects. We evaluated additional scenarios to estimate the individual effect of each mechanism.

RESULTS

Over 2020-2035, we estimate an additional 2,784 (95% uncertainty interval: 2,164-3,461) TB notifications and 1,138 (1,076-1,201) TB deaths in the United States associated with changes occurring during the COVID-19 pandemic. Mechanisms had offsetting effects - decreases in TB diagnosis rates led to more TB deaths and notifications, while reductions in contact rates reduced TB deaths and notifications. Immigration changes initially reduced TB deaths, but increased deaths and notifications over time. Higher TB mortality rates increased TB deaths, but decreased TB notifications.

CONCLUSIONS

While direct impacts of the COVID-19 pandemic occurred between 2020-2023, these changes may continue to influence TB incidence and mortality in future years.

MeSH

Mortality, Covid-19, Diagnosis, Pandemics, Communicable Diseases