Journal Article Review Ppublish 6 citations
PubMed: 40037936 DOI: 10.1016/j.tig.2025.02.001
Strategies for studying sex differences in brain aging.
Trends Genet 41(8):678-690
Authors: Victor A Ansere, Seung-Soo Kim, Francesca Marino, Katherine Morillo, Dena B Dubal, Coleen T Murphy, Yousin Suh, Bérénice A Benayoun
Affiliations
- Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
- Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032, USA.
- Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
- Department of Molecular Biology, Princeton University, Princeton, NJ, USA.
- Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
- Department of Molecular Biology, Princeton University, Princeton, NJ, USA; LSI Genomics, Princeton University, Princeton, NJ, USA.
- Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA.
- Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA; Molecular and Computational Biology Department, USC Dornsife College of Letters, Arts and Sciences, Los Angeles, CA 90089, USA; Biochemistry and Molecular Medicine Department, USC Keck School of Medicine, Los Angeles, CA 90089, USA.
Abstract
Studying sex effects and their underlying mechanisms is of major relevance to understanding brain health. Despite growing interests, experimentally studying sex differences, particularly in the context of aging, remains challenging. Since sex chromosomal content influences gonadal development, separating the effects of gonadal hormones and chromosomal factors requires specific model systems. Here, we highlight rodent and tractable models for examining sex dimorphism in brain and cognitive aging. In addition, we discuss multi-omic and bioinformatic approaches that yield biological insights from animal and human studies. This review provides a comprehensive overview of the diverse toolkit now available to advance our understanding of sex differences in brain aging.
MeSH
Genetics, Aging, Brain, Sex Chromosomes, Sex Characteristics, Sex, Gonadal Steroid Hormones, Sex Differences