Journal Article Comparative Study Ppublish
PubMed: 40049322 DOI: 10.1016/j.xphs.2025.103715
Transportation of protein drugs at hospital: Comparison of mechanical stress occurring during pneumatic transportation and hand-carried transport.
J Pharm Sci 114(5):103715
Authors: Pauline Barreau, Fréderic Feutry, Marie Abelé, Alexandre Villain, Ilyes Sakji, Guillaume Marliot
Affiliations
- Department of Pharmacy, Centre Oscar Lambret, Lille, France.
- Department of Pharmacy, Centre Oscar Lambret, Lille, France.
Abstract
In this study, we quantitatively characterize the mechanical shock generated in the pneumatic transport systems (PTS) in our center, determine the PTS pipeline with the highest risk of mechanical stress, and compare these results with hand-carried transport by trolleys or transportation boxes. Acceleration measurements were performed in triplicate for each of the five departments using a 3-axis accelerometer, which was fixed to three distinct experimental bags and a syringe. We measured the area under the curve (AUC) of the acceleration distribution with a threshold of 2 g, and the number of acceleration peaks (NAP) from >3 to 15 g-forces. The data obtained were calculated using bilateral Wilcoxon-Mann-Whitney non-parametric tests. The AUC and NAP g-forces for PTS were significantly greater than those for hand-carried transport by trolley and box (p < 0.001), which did not show any peak above the NAP. The PTS pipeline with more curves and redirection airlocks had the highest risk of mechanical stress, whereas no difference was observed per type of container. Transport by trolley had significantly greater (p < 0.001) AUC, NAP, and NAP than by box. Our results indicate that there is greater mechanical stress arising during PTS transportation than during hand-carried transport, preferentially in transportation boxes.
MeSH
Pharmaceutical Preparations, Stress, Physiological, Pharmacy, Transportation