Journal Article Review Ppublish 36 citations
PubMed: 40052109 DOI: 10.1038/s44324-024-00045-y
Pulling back the mitochondria's iron curtain.
NPJ Metab Health Dis 3(1):6
Authors: Shani Ben Zichri-David, Liraz Shkuri, Tslil Ast
Affiliations
- Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, 7610001 Israel.
Abstract
Mitochondrial functionality and cellular iron homeostasis are closely intertwined. Mitochondria are biosynthetic hubs for essential iron cofactors such as iron-sulfur (Fe-S) clusters and heme. These cofactors, in turn, enable key mitochondrial pathways, such as energy and metabolite production. Mishandling of mitochondrial iron is associated with a spectrum of human pathologies ranging from rare genetic disorders to common conditions. Here, we review mitochondrial iron utilization and its intersection with disease.
MeSH
Mitochondria