Journal Article Epublish
PubMed: 40052198 DOI: 10.7189/jogh.15.04047
Impact of intensive health education on influenza vaccination and acute exacerbations in outpatients with chronic obstructive pulmonary disease: a real-world study.
J Glob Health 15:04047
Authors: Cong Liu, Qing Song, Ling Lin, Tao Li, Ping Zhang, Yuqin Zeng, Yating Peng, Yan Chen, Shan Cai, Ping Chen
Affiliations
- Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China. Research Unit of Respiratory Disease, Central South University, Changsha, China. Clinical Medical Research Centre for Pulmonary and Critical Care Medicine in Hunan Province, Changsha, China. Diagnosis and Treatment Center of Respiratory Disease in Hunan Province, Changsha, Hunan, China.
Abstract
Background
The influenza vaccination rate of chronic obstructive pulmonary disease (COPD) patients in China was very low. In this study, we aimed to evaluate the effect of clinician-led intensive health education on influenza vaccination in outpatients with COPD and the effect of influenza vaccination on the risk of acute exacerbations in the real world.
Methods
Participants were from the Real World Research of Diagnosis and Treatment of COPD study, a real-world prospective cohort study. COPD patients were included from December 2016 to April 2023 and followed up for one year. In January 2022, clinicians began strengthening health education for outpatients with COPD. We identified patients visiting the clinic from January 2022 to April 2023 as the intensive health education group and those visiting from December 2016 to December 2021 as the control group. We analysed factors associated with influenza vaccination and the effect of influenza vaccine on acute exacerbations by multivariate analysis.
Results
7834 patients were included. Compared with the control group, the intensive health education group had a higher rate of influenza vaccination (1.6% vs. 12.2%, P < 0.01). Smoking cessation, high school education or above, influenza vaccination in the past year and intensive health education were independently associated with influenza vaccination. Influenza vaccination reduced the incidence of future acute exacerbations (adjusted odds ratio (aOR) = 0.48; 95% confidence interval (CI) = 0.33-0.68, P < 0.01), frequent acute exacerbations (aOR = 0.47; 95% CI = 0.27-0.82, P = 0.01), and severe acute exacerbation (aOR = 0.38; 95% CI = 0.23-0.63, P < 0.01) in COPD patients.
Conclusions
Influenza vaccination reduced the risk of future acute exacerbations in patients with COPD. Clinician-led intensive health education can improve the influenza vaccination of outpatients with COPD, and clinicians and policymakers should pay attention to and apply this method.
MeSH
Vaccines, Global Health, Vaccination, Pulmonary Disease, Chronic Obstructive, Influenza, Human, Health Education, Lung Diseases, Outpatients, Education, Lung Diseases, Obstructive