Journal Article Ppublish
PubMed: 40061695 DOI: 10.4103/jpbs.jpbs_1253_24
Evaluating Anti- Potential of . Extract against Healthcare-Associated Infections in Tertiary Hospitals of Al-Kharj Governorate: An Study.
J Pharm Bioallied Sci 16(Suppl 5):S4649-S4654
Authors: Mohammed S Khan, Md Nadeem Bari
Affiliations
- Department of Basic Medical Sciences, College of Medicine, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Abstract
Background
Healthcare-associated infections (HAIs) caused by pathogens are a significant concern in tertiary hospitals worldwide, including those in Al-Kharj, Saudi Arabia. This study aimed to explore the bioactive compounds from and evaluate their antimicrobial activity against pathogens.
Materials and Methods
Methanolic extracts of the stem were prepared and subjected to phytochemical analysis, thin-layer chromatography (TLC), and antimicrobial testing using the well-diffusion method. The minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and cytotoxicity (MTT assay) were also evaluated.
Results
The extract contained several major phytochemicals with significant activity against pathogens. The MIC values were 50 mg/mL for , , and , 100 mg/mL for and , and 25 mg/mL for . The MBC values were 25 mg/mL for and 100 mg/mL for the other pathogens.
Conclusion
The methanolic extract of . demonstrated potent antimicrobial activity, with relatively low MIC and MBC values against pathogens responsible for HAIs.
MeSH
Tertiary Care Centers, Cross Infection, Infections, Phytochemicals