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Publications

Journal Article Review Epublish

PubMed: 40062355 DOI: 10.20411/pai.v10i2.791

A Year in Review on Tuberculosis and Non-tuberculous Mycobacteria Disease: A 2025 Update for Clinicians and Scientists.

Pathog Immun 10(2):1-45

Authors: Christoph Lange, Graham Bothamley, Gunar Günther, Lorenzo Guglielmetti, Irina Kontsevaya, Liga Kuksa, Berit Lange, Natalie Lorent, Francesca Saluzzo, Martina Sester, Marc Tebruegge, Simone Tunesi, Conor Tweed

Affiliations

  • Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Borstel, Germany. Clinical Tuberculosis Unit, German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems, Germany. Respiratory Medicine and International Health, University of Lübeck, Germany. Baylor College of Medicine and Texas Children's Hospital, Global TB Program, Houston, Texas.
  • Homerton University Hospital, London, United Kingdom.
  • Queen Mary University of London, London, United Kingdom.
  • London School of Hygiene and Tropical Medicine, London, United Kingdom.
  • Department of Pulmonology, Allergology and Clinical Immunology, Inselspital Bern, Bern University Hospital, Bern, Switzerland.
  • Department of Clinical Sciences, School of Medicine, University of Namibia, Windhoek, Namibia.
  • Sorbonne Université, INSERM, U1135, Centre d'Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, France.
  • Assistance Publique Hôpitaux de Paris, Groupe Hospitalier Universitaire Sorbonne Université, Hôpital Pitié-Salpetrière, Centre National de Reference des Mycobactéries et de la Resistance des Mycobactéries aux Antituberculeux, Paris, France.
  • Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, United Kingdom.
  • Tuberculosis and Lung Disease clinic, Riga East University hospital, Riga, Latvia.
  • Department of Epidemiology, Helmholtz Centre for Infection Research.
  • German Center for Infection Research, TI BBD.
  • Department of Respiratory Diseases, University Hospital Leuven, Leuven, Belgium.
  • Department of Chronic Diseases, Metabolism and Aging, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium.
  • IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Vita salute San Raffaele University, Milan, Italy.
  • Department of Transplant and Infection Immunology.
  • Center for Gender-specific Biology and Medicine (CGBM), Saarland University, Homburg, Germany.
  • Department of Child and Adolescent Medicine & Austrian National Reference Centre for Childhood Tuberculosis, Klinik Ottakring, Vienna Healthcare Group, Vienna, Austria.
  • Infectious Diseases Network, Vienna Healthcare Group, Vienna, Austria.
  • Department of Paediatrics, University of Melbourne, Parkville, Australia.
  • Infectious Diseases Unit, AOU SS Antonio e Biagio e C. Arrigo, Alessandria, Italy.
  • MRC Clinical Trials Unit, University College London, London, United Kingdom.

Abstract

Background

In the field of tuberculosis and non-tuberculous mycobacterial (NTM) disease we are looking back on an exciting year 2024 with more than 10,000 publications listed in PubMed.

Methods

Our aim, to review the scientific literature of the year 2024, is challenged by the enormous number of publications. Therefore, if your article is not included or your favorite field of mycobacteriology not covered, please forgive us. Our "Year in Review" is very much clinically oriented with lesser emphasis on basic science, microbiology, and biotechnology.

Results

Members of the steering committee of the Tuberculosis Network European Trials group (TBnet; www.tbnet.eu) report on 139 publications in the fields of epidemiology, prevention, diagnosis, and treatment of tuberculosis and NTM diseases published in 2024 that we found particularly important. We report publications separately for tuberculosis in children and adults and for NTM disease and provide a brief overview of newer technologies in the diagnostic pipeline. Furthermore, we summarize priorities for tuberculosis and NTM disease research, development, and implementation, all of which represent the perspective of our combined clinical experience.

Conclusions

This Year in Review provides a concise summary of the clinically relevant highlights of the published literature in tuberculosis and NTM diseases in 2024.

MeSH

Mycobacterium, Tuberculosis, Nontuberculous Mycobacteria