Journal Article Review Epublish
PubMed: 40076578 DOI: 10.3390/ijms26051955
The Essential Role of Mitochondrial Dynamics in Viral Infections.
Int J Mol Sci 26(5)
Authors: Xujie Duan, Rui Liu, Wenjing Lan, Shuying Liu
Affiliations
- College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China.
- Inner Mongolia Key Laboratory of Basic Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China.
- Key Laboratory of Clinical Diagnosis and Treatment Technology for Animal Disease, Ministry of Agriculture, Hohhot 010018, China.
- College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China. Inner Mongolia Key Laboratory of Basic Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China. Key Laboratory of Clinical Diagnosis and Treatment Technology for Animal Disease, Ministry of Agriculture, Hohhot 010018, China.
Abstract
Mitochondria are dynamic organelles that play crucial roles in energy production, metabolic balance, calcium homeostasis, apoptosis, and innate immunity, and are key determinants of cell fate. They are also targets for viral invasion of the body. Many viral proteins target mitochondria, controlling mitochondrial morphology, metabolism, and immune response, thereby achieving immune evasion, promoting their proliferation, and accelerating the infection process. Mitochondrial quality control is key to maintaining normal physiological functions and mitochondrial homeostasis. Dysregulation of mitochondrial dynamics is closely related to the development of many diseases. New roles of mitochondrial dynamics in viral infection are constantly being discovered. Viruses change mitochondrial dynamics by targeting mitochondria to achieve a persistent state of infection. Currently, understanding of mitochondrial dynamics during viral infection is limited. Research on the impact of viral proteins on mitochondrial dynamics provides a foundation for investigating the pathogenesis of viral infections, the disease process, and identifying potential therapeutic targets. This review focuses on the connection between viral infection and mitochondrial dynamics and priority areas for research on virus-mediated mitochondrial immunity, provides insight into the regulation of mitochondrial dynamics by viruses targeting mitochondria, and explores potential means of mitochondrial-mediated control and treatment of viral diseases.
MeSH
Homeostasis, Mitochondria, Mitochondrial Dynamics, Viruses, Immunity, Therapeutics, Viral Proteins, Immunity, Innate, Apoptosis, Infections, Virus Diseases