Journal Article Systematic Review Ppublish
PubMed: 40079963 DOI: 10.1080/21645515.2025.2474772
Factors affecting the impact of COVID-19 vaccination on post COVID-19 conditions among adults: A systematic literature review.
Hum Vaccin Immunother 21(1):2474772
Authors: Abby E Rudolph, Nadine Al Akoury, Natalija Bogdanenko, Kristen Markus, Isabelle Whittle, Olivia Wright, Hammam Haridy, Julia R Spinardi, John M McLaughlin, Moe H Kyaw
Affiliations
- Pfizer Vaccines, Collegeville, USA.
- Pfizer Emerging Markets, Aoukar, Lebanon.
- Pfizer Vaccines, London, UK.
- Adelphi Values PROVE, Bollington, UK.
- Pfizer Emerging Markets, Dubai, UAE.
- Pfizer Emerging Markets, Sao Paulo, Brazil.
Abstract
This systematic literature review summarizes the evidence across 56 publications and pre-prints (January 2020-July 2023) with low-risk of bias based on JBI critical appraisal, that report adjusted estimates for the relationship between COVID-19 vaccination and Post-COVID-19 Condition (PCC) by timing of vaccination relative to infection or PCC-onset. Comparisons of adjusted vaccine effectiveness (aVE) against ≥1 PCC (vs. unvaccinated) across study characteristics known to impact PCC burden or VE against other COVID-19 endpoints were possible for 31 studies where vaccination preceded infection. Seventy-seven percent of pre-infection aVE estimates were statistically significant (range: 7%-95%). Statistically significant pre-infection aVE estimates were slightly higher for mRNA (range: 14%-84%) than non-mRNA vaccines (range: 16%-38%) and aVE ranges before and during Omicron overlapped. Our findings suggest that COVID-19 vaccination before SARS-CoV-2 infection reduces the risk of PCC regardless of vaccine type, number of doses received, PCC definition, predominant variant, and severity of acute infections included.
MeSH
Vaccines, Vaccination, Covid-19, Infections
Cited by
- Adult Vaccinations Today-Innovations and Challenges for the Coming Years. Vaccines (Basel), 2025