Journal Article Review Epublish
PubMed: 40083779 DOI: 10.3389/fmicb.2025.1536778
Recent insights and advances in gut microbiota's influence on host antiviral immunity.
Front Microbiol 16:1536778
Authors: Ying Liu, Danying Yan, Ran Chen, Yingying Zhang, Chuwen Wang, Guoqing Qian
Affiliations
- Health Science Center, Ningbo University, Ningbo, Zhejiang, China.
- Department of Infectious Diseases, The First Affiliated Hospital, Ningbo University, Ningbo, Zhejiang, China.
- Cixi Biomedical Research Institute, Wenzhou Medical University, Wenzhou, Zhejiang, China.
- Health Science Center, Ningbo University, Ningbo, Zhejiang, China. Department of Infectious Diseases, The First Affiliated Hospital, Ningbo University, Ningbo, Zhejiang, China.
Abstract
A diverse array of microbial organisms colonizes the human body, collectively known as symbiotic microbial communities. Among the various pathogen infections that hosts encounter, viral infections represent one of the most significant public health challenges worldwide. The gut microbiota is considered an important biological barrier against viral infections and may serve as a promising target for adjuvant antiviral therapy. However, the potential impact of symbiotic microbiota on viral infection remains relatively understudied. In this review, we discuss the specific regulatory mechanisms of gut microbiota in antiviral immunity, highlighting recent advances in how gut microbiota regulate the host immune response, produce immune-related molecules, and enhance the host's defense against viruses. Finally, we also discuss the antiviral potential of oral probiotics.
MeSH
Immunity, Virome, Gastrointestinal Microbiome, Antiviral Agents, Microbiota, Infections, Virus Diseases