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Journal Article Review Epublish 1 citation

PubMed: 40098005 DOI: 10.1186/s12951-025-03199-z

Functions and application of circRNAs in vascular aging and aging-related vascular diseases.

J Nanobiotechnology 23(1):216

Authors: Sha-Qi He, Bei Huang, Feng Xu, Jun-Jie Yang, Cong Li, Feng-Rong Liu, Ling-Qing Yuan, Xiao Lin, Jun Liu

Affiliations

  • Department of Radiology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China.
  • National Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China.
  • Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Ãœrümqi, 830054, China.
  • Department of Anesthesiology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China.
  • Department of Radiology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China.
  • Department of Radiology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China. Clinical Research Center for Medical Imaging in Hunan Province, Quality Control Center in Hunan Province, Changsha, 410011, China.

Abstract

Circular RNAs (circRNAs), constituting a novel class of endogenous non-coding RNAs generated through the reverse splicing of mRNA precursors, possess the capacity to regulate gene transcription and translation. Recently, the pivotal role of circRNAs in controlling vascular aging, as well as the pathogenesis and progression of aging-related vascular diseases, has garnered substantial attention. Vascular aging plays a crucial role in the increased morbidity and mortality of the elderly. Endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) are crucial components of the intima and media layers of the vascular wall, respectively, and are closely involved in the mechanisms underlying vascular aging and aging-related vascular diseases. The review aims to provide a comprehensive exploration of the connection between circRNAs and vascular aging, as well as aging-related vascular diseases. Besides, circRNAs, as potential diagnostic markers or therapeutic targets for vascular aging and aging-related vascular diseases, will be discussed thoroughly, along with the challenges and limitations of their clinical application. Investigating the role and molecular mechanisms of circRNAs in vascular aging and aging-related vascular diseases will provide a novel insight into early diagnosis and therapy, and even effective prognosis assessment of these conditions.

MeSH

Cells, Genes, Aging, Rna, Circular, Vascular Diseases, Therapeutics, Nanotechnology

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