Case Reports Journal Article Epublish 2 citations
PubMed: 40104149 DOI: 10.3389/fcvm.2025.1487543
Metagenomic next-generation sequencing identifies native valve Aspergillus fumigatus endocarditis with cerebral involvement: a case report.
Front Cardiovasc Med 12:1487543
Authors: Weibing Wu, Jingjing Xu, Jianling Ruan, Baoping Tian, Nanxia Xuan
Affiliations
- Department of Critical Care Medicine, Qingyuan People's Hospital, Lishui, China.
- Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
- Department of Ultrasound in Medicine, Qingyuan People's Hospital, Lishui, China.
- Department of Critical Care Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Abstract
Aspergillus endocarditis is a rare but highly fatal condition, particularly in immunocompromised patients. This case report describes a 74-year-old male with native valve Aspergillus fumigatus endocarditis and intracranial infection. Diagnosis was complicated by atypical presentation and negative blood cultures, but metagenomic next-generation sequencing (mNGS) enabled rapid identification of the pathogen. This case is notable for being the first to document Aspergillus fumigatus endocarditis with cerebral involvement confirmed by mNGS, highlighting the importance of early diagnosis and advanced diagnostic tools in improving outcomes.
MeSH
High-Throughput Nucleotide Sequencing, Endocarditis, Metagenomics, Aspergillus, Diagnosis, Aspergillus Fumigatus