Journal Article Review Epublish 15 citations
PubMed: 40104324 DOI: 10.1177/17562848251327167
Therapeutic potential of fecal microbiota transplantation in colorectal cancer based on gut microbiota regulation: from pathogenesis to efficacy.
Therap Adv Gastroenterol 18:17562848251327167
Authors: Chen Gu, Gengyu Sha, Binbin Zeng, Herong Cao, Yibo Cao, Dong Tang
Affiliations
- Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, China.
- The Second School of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.
- Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou University, Yangzhou 225000, China. The Yangzhou Clinical College of Xuzhou Medical University, Xuzhou Medical University, Xuzhou, 221000, China. Department of General Surgery, Institute of General Surgery, Northern Jiangsu People's Hospital, Yangzhou University, Yangzhou, 225000, China. Northern Jiangsu People's Hospital, Clinical Teaching Hospital of Medical School, Nanjing University, Nanjing, 210000, China.
Abstract
Colorectal cancer (CRC) remains a leading cause of cancer-related deaths worldwide, with its progression intricately linked to gut microbiota dysbiosis. Disruptions in microbial homeostasis contribute to tumor initiation, immune suppression, and inflammation, establishing the microbiota as a key therapeutic target. Fecal microbiota transplantation (FMT) has emerged as a transformative approach to restore microbial balance, enhance immune responses, and reshape the tumor microenvironment. This review explores the mechanisms underlying FMT's therapeutic potential, evaluates its advantages over other microbiota-based interventions, and addresses challenges such as donor selection, safety concerns, and treatment standardization. Looking forward, the integration of FMT into personalized CRC therapies requires robust clinical trials and the identification of predictive biomarkers to optimize its efficacy and safety.
MeSH
Safety, Fecal Microbiota Transplantation, Neoplasms, Therapeutics, Colorectal Neoplasms, Gastrointestinal Microbiome, Transplantation, Microbiota