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Journal Article Epublish

PubMed: 40122536 DOI: 10.1136/bmjopen-2024-093397

Global, regional and national burden and quality of care index (QCI) of leukaemia and brain and central nervous system tumours in children and adolescents aged 0-19 years: a systematic analysis of the Global Burden of Disease Study 1990-2019.

BMJ Open 15(3):e093397

Authors: Yanxin Bi, Kepei Huang, Minmin Wang, Yinzi Jin, Zhi-Jie Zheng

Affiliations

  • Department of Global Health, School of Public Health, Peking University, Beijing, China. Institute for Global Health and Development, Peking University, Beijing, China.
  • Department of Global Health, School of Public Health, Peking University, Beijing, China.
  • Institute for Global Health and Development, Peking University, Beijing, China.

Abstract

OBJECTIVES

This study aimed to evaluate the global, regional and national disparities in the quality of care for leukaemia and brain and central nervous system (CNS) tumours among children and adolescents aged 0-19 years. We also assessed temporal trends in the quality of care index (QCI) and explored associations with sociodemographic development levels, gender and age.

SETTING

The study used data from the Global Burden of Disease (GBD) 2019 database, covering 204 countries and territories. The analysis included global, regional and national levels of care, stratified by sociodemographic index (SDI), gender and age groups.

PARTICIPANTS

The study included children and adolescents aged 0-19 years diagnosed with leukaemia or CNS tumours. Data on incidence, prevalence, mortality and disability-adjusted life years (DALYs) were extracted from the GBD 2019 database.

PRIMARY AND SECONDARY OUTCOME MEASURES

The primary outcome was the QCI, constructed using principal component analysis from four secondary indicators: years of life lost to years lived with disability ratio, DALYs to prevalence ratio, mortality to incidence ratio and prevalence to incidence ratio. Secondary outcomes included temporal trends in QCI, gender disparity ratios (GDRs) and correlations between QCI and SDI levels.

RESULTS

In 2019, leukaemia and CNS tumours accounted for 132 194 deaths globally. The QCI for leukaemia was 74.71, while for CNS tumours, it was 56.59. From 1990 to 2019, the QCI for CNS tumours increased significantly (estimated annual percentage change (EAPC)=1.45, 95% CI: 1.41 to 1.50), whereas the QCI for leukaemia showed a declining trend in middle and low-middle SDI regions (EAPC=-0.13, 95% CI: -0.16 to -0.09). Western Europe had the highest QCI for leukaemia (94.50), while South Asia had the lowest (57.64). Boys had lower QCI scores than girls, and the gender disparity in CNS tumours widened over time (GDR increased from 1.147 in 1990 to 1.160 in 2019). QCI was positively correlated with SDI levels (leukaemia: r=0.591, p<0.001; CNS tumours: r=0.812, p<0.001).

CONCLUSIONS

This study highlights significant disparities in the quality of childhood cancer care across regions, development levels and genders. While global QCI for CNS tumours improved, leukaemia care quality declined in middle and low-middle SDI regions. Boys and populations in low SDI regions are particularly vulnerable to poor care. Policymakers should prioritise targeted interventions to address these disparities, improve access to quality care and reduce the global burden of childhood cancer.

MeSH

Mortality, Incidence, Brain, Neoplasms, Global Burden Of Disease, Central Nervous System, Aged, Adolescent, Prevalence, Cost Of Illness, Nervous System, Child