Journal Article Ppublish 6 citations
PubMed: 40126899 DOI: 10.1093/infdis/jiaf149
Respiratory Syncytial Virus Humoral Antibody Responses in Older Adults After Vaccination or Infection.
J Infect Dis 231(6):e1146-e1150
Authors: Edward E Walsh, Michael Peasley, Angela R Branche, Ann R Falsey
Affiliations
- Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Abstract
BACKGROUND
Immunity to respiratory syncytial virus (RSV) is short lived following infection. We determined if recently licensed RSV preF vaccines induce better immune responses than infection.
METHODS
Serum preF binding and neutralizing antibody to RSV A and B was measured in older adults at baseline and 30 days after RSV infection or vaccination with 2 licensed RSV preF protein vaccines.
RESULTS
Vaccination induced higher serum preF binding antibody and neutralizing responses than RSV infection (A2 RSV, 3306 vs 1254, P < .0001; B1 RSV, 5153 vs 2186, P < .0001).
CONCLUSIONS
Vaccination with preF protein vaccines induce better humoral immune responses than RSV infection in older adult.
MeSH
Respiratory Syncytial Viruses, Antibody Formation, Vaccines, Vaccination, Viruses, Immunity, Communicable Diseases, Infections, Respiratory Syncytial Virus Infections