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Publications

Journal Article Review Epublish 23 citations

PubMed: 40136347 DOI: 10.3390/curroncol32030143

Breast Cancer and Tumor Microenvironment: The Crucial Role of Immune Cells.

Curr Oncol 32(3)

Authors: Tânia Moura, Paula Laranjeira, Olga Caramelo, Ana M Gil, Artur Paiva

Affiliations

  • Flow Cytometry Unit, Department of Clinical Pathology, Hospitais da Universidade de Coimbra, Unidade Local de Saúde de Coimbra, 3000-076 Coimbra, Portugal. Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
  • Flow Cytometry Unit, Department of Clinical Pathology, Hospitais da Universidade de Coimbra, Unidade Local de Saúde de Coimbra, 3000-076 Coimbra, Portugal.
  • Group of Environmental Genetics of Oncobiology (CIMAGO), Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.
  • Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-504 Coimbra, Portugal.
  • Clinical Academic Center of Coimbra (CACC), 3000-061 Coimbra, Portugal.
  • Center of Neurosciences and Cell (CNC), University of Coimbra, 3000-504 Coimbra, Portugal.
  • Gynecology Department, Hospitais da Universidade de Coimbra, Unidade Local de Saúde de Coimbra, 3000-075 Coimbra, Portugal.
  • Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
  • CICECO-Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
  • Ciências Biomédicas Laboratoriais, Instituto Politécnico de Coimbra, ESTESC-Coimbra Health School, 3046-854 Coimbra, Portugal.

Abstract

Breast cancer is the most common type of cancer in women and the second leading cause of death by cancer. Despite recent advances, the mortality rate remains high, underlining the need to develop new therapeutic approaches. The complex interaction between cancer cells and the tumor microenvironment (TME) is crucial in determining tumor progression, therapy response, and patient prognosis. Understanding the role of immune cells in carcinogenesis and tumor progression can help improve targeted therapeutic options, increasing the likelihood of a favorable prognosis. Therefore, this review aims to critically analyze the complex interaction between tumor cells and immune cells, emphasizing the clinical and therapeutic implications. Additionally, we explore advances in immunotherapies, with a focus on immune checkpoint inhibitors.

MeSH

Cells, Breast Neoplasms, Neoplasms, Breast, Immune System, Therapeutics, Tumor Microenvironment, Prognosis

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