Journal Article Epublish
PubMed: 40136439 DOI: 10.3390/cimb47030185
Anti-Infective Screening of Selected Nine Cannabinoids Against and Influenza A (H5N1) Neuraminidases, and SARS-CoV-2 Main Protease and Spike Protein Interactions.
Curr Issues Mol Biol 47(3)
Authors: Thanet Pitakbut, Oliver Kayser
Affiliations
- Pharmaceutical Biology, Department of Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91058 Erlangen, Germany.
- Technical Biochemistry, Department of Biochemical and Chemical Engineering, TU Dortmund University, 44227 Dortmund, Germany.
Abstract
Recently, cannabinoids have gained scientific interest as a promising anti-infective natural product class, as reported in several studies. However, the existing knowledge is mainly limited to common cannabinoids like THC and CBD. Therefore, this study aims to fill the knowledge gap by investigating the anti-infective potential of nine selected cannabinoids (both common and rare cannabinoids): THC, CBD, CBC, CBE, CBF, CBG, CBL, CBN, and CBT against and Influenza A (H5N1) neuraminidases and SARS-CoV-2 main protease and spike protein-human ACE2 interaction using a standard in vitro biochemical enzyme-binding assay. As a result, to the authors' knowledge, this study is the first to demonstrate the most promising effect of CBG over others in its class against and influenza A (H5N1) neuraminidases and SARS-CoV-2 main protease and spike protein-human ACE2 interaction. In comparison to CBG, CBD and THC were the second and third most promising candidates. Meanwhile, the other derivatives, such as CBC, CBE, CBF, CBL, CBN, and CBT, showed at least one anti-infective effect. Our findings during the early drug discovery process indicate a promising anti-infective potential of cannabinoids, which can be considered for further investigation in a biological setup.
MeSH
Sars-Cov-2, Influenza, Human, Peptide Hydrolases, Severe Acute Respiratory Syndrome-Related Coronavirus, Cannabinoids