Journal Article Epublish
PubMed: 40142490 DOI: 10.3390/microorganisms13030597
Lentinan Reduces Transmission Efficiency of COVID-19 by Changing Aerodynamic Characteristic of Exhaled SARS-CoV-2 Aerosols in Golden Hamsters.
Microorganisms 13(3)
Authors: Cheng Zhang, Jiaming Li, Huan Cui, Yifei Jin, Zhaoliang Chen, Lei Zhang, Sihui Song, Bing Lu, Zhongyi Wang, Zhendong Guo
Affiliations
- Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 573 Tulip Street, Changchun 130122, China. State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, 573 Tulip Street, Changchun 130122, China. College of Veterinary Medicine, Hebei Agricultural University, 2596 Lucky South Street, Baoding 071000, China.
- Beijing Institute of Biotechnology, 20 Dongdajie Road, Beijing 100071, China.
- Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 573 Tulip Street, Changchun 130122, China. State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, 573 Tulip Street, Changchun 130122, China.
Abstract
Lentinan (LNT) was found to reduce the aerosol transmission rate between golden hamsters from 100% (9/9) to 44.4% (4/9). The viral loads in the respiratory system, including the nasal turbinate, trachea, and lung, were significantly reduced in the infected golden hamsters that received LNT treatment. Furthermore, the amount of exhaled virus aerosols in hamsters treated with LNT was significantly lower than that in untreated hamsters throughout the entire disease progression. In detail, the amounts of virus-laden particles with aerodynamic diameters less than 5 µm exhibited a significant decreasing trend following LNT treatment. Moreover, the detection rate of infectious SARS-CoV-2 in each stage of the Anderson-6 sampler exhibited a decreasing trend following LNT treatment post-infection. In summary, our findings indicate that LNT therapy represents a promising therapeutic candidate for the treatment of COVID-19 patients. Meanwhile, during the course of treatment, LNT has the potential to reduce viral infectivity in affected individuals.
MeSH
Sars-Cov-2, Aerosols, Covid-19, Viruses, Therapeutics, Severe Acute Respiratory Syndrome-Related Coronavirus, Lentinan