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Publications

Journal Article Review Epublish

PubMed: 40149464 DOI: 10.3390/genes16030313

LncRNAs Ride the Storm of Epigenetic Marks.

Genes (Basel) 16(3)

Authors: Giulia Gaggi, Clinton Hausman, Soomin Cho, Brianna C Badalamenti, Bon Q Trinh, Annalisa Di Ruscio, Simone Ummarino

Affiliations

  • Department of Medicine and Aging Sciences, "G. D'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.
  • UdA-TechLab, "G. D'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.
  • Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA. Beth Israel Deaconess Medical Center, Cancer Research Institute, Boston, MA 02215, USA. Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02115, USA.
  • Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
  • Molecular Genetics & Epigenetics Program, University of Virginia Comprehensive Cancer Center, Charlottesville, VA 22908, USA.
  • Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.
  • Beth Israel Deaconess Medical Center, Cancer Research Institute, Boston, MA 02215, USA.
  • Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02115, USA.
  • Department of Biology, Tufts University, Medford, MA 02155, USA.

Abstract

Advancements in genome sequencing technologies have uncovered the multifaceted roles of long non-coding RNAs (lncRNAs) in human cells. Recent discoveries have identified lncRNAs as major players in gene regulatory pathways, highlighting their pivotal role in human cell growth and development. Their dysregulation is implicated in the onset of genetic disorders and age-related diseases, including cancer. Specifically, they have been found to orchestrate molecular mechanisms impacting epigenetics, including DNA methylation and hydroxymethylation, histone modifications, and chromatin remodeling, thereby significantly influencing gene expression. This review provides an overview of the current knowledge on lncRNA-mediated epigenetic regulation of gene expression, emphasizing the biomedical implications of lncRNAs in the development of different types of cancers and genetic diseases.

MeSH

Cells, Genes, Genomics, Neoplasms, Chromatin, Genetic Diseases, Inborn, Gene Expression

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