Journal Article Review Epublish
PubMed: 40149584 DOI: 10.3390/biomedicines13030607
LGR4 (GPR48): The Emerging Inter-Bridge in Osteoimmunology.
Biomedicines 13(3)
Authors: Wonbong Lim
Affiliations
- Department of Orthopaedic Surgery, Chosun University, Gwangju 61453, Republic of Korea. Laboratory of Orthopaedic Research, Chosun University, Gwangju 61453, Republic of Korea. Regional Leading Research Center, Chonnam National University, Yeosu 59626, Republic of Korea. Department of Premedical Program, School of Medicine, Chosun University, Gwangju 61452, Republic of Korea.
Abstract
Leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4), a member of the G-protein-coupled receptor (GPCR) family, has been implicated in various regulatory functions across multiple differentiation stages and numerous target sites in bone diseases. Therefore, LGR4 is a potential regulator of nuclear factor-κB ligand (RANKL) during osteoclast differentiation. However, a comprehensive investigation of its functions and applications in bone immunology is lacking. This review discusses the molecular characteristics, signaling pathways, and role of LGR4 in osteoimmunology, with a particular focus on its interactions with RANKL during osteoclast differentiation, while identifying gaps that warrant further research.
MeSH
Osteoprotegerin, Osteoporosis, Osteoclasts, Immunology