Journal Article Epublish 1 citation
PubMed: 40149718 DOI: 10.3390/biomedicines13030742
Metabolic Disruptions and Non-Communicable Disease Risks Associated with Long-Term Particulate Matter Exposure in Northern Thailand: An NMR-Based Metabolomics Study.
Biomedicines 13(3)
Authors: Churdsak Jaikang, Giatgong Konguthaithip, Yutti Amornlertwatana, Narongchai Autsavapromporn, Sirichet Rattanachitthawat, Nitip Liampongsabuddhi, Tawachai Monum
Affiliations
- Department of Forensic Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
- Metabolomics Research Group for Forensic Medicine and Toxicology, Department of Forensic Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
- Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
- General Education Office, Faculty Agricultural Technology, Burapha University, Sakaeo 27160, Thailand.
- Department of Forensic Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. Metabolomics Research Group for Forensic Medicine and Toxicology, Department of Forensic Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Abstract
: Particulate matter (PM) is a primary health hazard associated with metabolic pathway disruption. Population characteristics, topography, sources, and PM components contribute to health impacts. : In this study, NMR-based metabolomics was used to evaluate the health impacts of prolonged exposure to PM. Blood samples ( = 197) were collected from healthy volunteers in low- (control; CG) and high-exposure areas (exposure; EG) in Northern Thailand. Non-targeted metabolite analysis was performed using proton nuclear magnetic resonance spectroscopy (H-NMR). : Compared to CG, EG showed significantly increased levels of dopamine, N6-methyladenosine, 3-hydroxyproline, 5-carboxylcytosine, and cytidine ( < 0.05), while biopterin, adenosine, L-Histidine, epinephrine, and norepinephrine were significantly higher in CG ( < 0.05). These metabolic disturbances suggest that chronic exposure to particulate matter (PM) impairs energy and amino acid metabolism while enhancing oxidative stress, potentially contributing to the onset of non-communicable diseases (NCDs) such as cancer and neurodegenerative conditions. : This study highlighted the connection between sub-chronic PM2.5 exposure, metabolic disturbances, and an increased risk of non-communicable diseases (NCDs), stressing the critical need for effective PM2.5 reduction strategies in Northern Thailand.
MeSH
Stress, Physiological, Adenosine, Noncommunicable Diseases, Epinephrine, Metabolomics, Histidine, Communicable Diseases, Particulate Matter