Journal Article Review Epublish
PubMed: 40150639 DOI: 10.3390/children12030358
Respiratory Microbiota and Health Risks in Children with Cerebral Palsy: A Narrative Review.
Children (Basel) 12(3)
Authors: Pavlina Peneva, Rouzha Pancheva, Silviya P Nikolova
Affiliations
- First Department of Internal Disease, Faculty of Medicine, Medical University, 9002 Varna, Bulgaria.
- Department of Hygiene and Epidemiology, Faculty of Public Health, Medical University, 9002 Varna, Bulgaria.
- Department of Social Medicine and Healthcare Organization, Faculty of Public Health, Medical University, 9002 Varna, Bulgaria.
Abstract
Children diagnosed with cerebral palsy (CP) frequently face a range of intricate health challenges that go beyond their main condition. Respiratory problems represent one of the most crucial factors contributing to morbidity and mortality. This review employed a systematic approach to identify and collate recent findings on the respiratory microbiota in children with CP. The review emphasizes notable microbial alterations in the respiratory systems of children with CP, marked by a decrease in beneficial bacteria (such as spp. and spp.) and an increase in opportunistic pathogens like , , and These changes probably increase the vulnerability of children with CP to frequent respiratory infections, ongoing inflammation, and infections that are resistant to antibiotics. Key factors influencing the composition of microbiota include living in urban areas, socioeconomic factors, seasonal variations, vaccination status, dietary habits, breastfeeding, etc. Although new research has shed significant light on this topic, there are still considerable gaps in our understanding of how these microbial communities develop and interact with the immune responses of the host. Future research should focus on longitudinal studies to track microbiota changes over time and identify interventions that optimize respiratory health in CP.
MeSH
Lung, Research, Paralysis, Cerebral Palsy, Microbiota, Infections, Child