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Publications

Journal Article Epublish

PubMed: 40151613 DOI: 10.1007/s10068-024-01761-3

The combination of Korean Sajabal mugwort (Artemisia princeps Pampanini) and green tea (Camellia sinensis) extracts and that of their major constituents improved blood flow in vitro and in vivo.

Food Sci Biotechnol 34(8):1725-1735

Authors: Moon Jeong Son, Ga Yeon Lee, Jin Tae Kim, Yimeng Zhou, Jung Won Kwon, Jeongyoon Choi, Kyungsuk Park, Jungmin Lee, Yujin Ko, Shuai Qiu, Jong Hun Kim, Hong Jin Lee

Affiliations

  • Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546 Republic of Korea. GreenTech-Based Food Safety Research Group, Chung-Ang University, BK21 Four, Anseong, 17546 Republic of Korea.
  • Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546 Republic of Korea.
  • Department of Next Generation Applied Sciences, Graduate School, Sungshin Women's University, Seoul, 01133 Republic of Korea.
  • R&D Center, CINNAMON LAB Co. Ltd, Seoul, 06628 Republic of Korea.
  • Department of Clinical Nutrition, Graduate School of Clinical Biohealth, Ewha Womans University, Seoul, 03760 Republic of Korea.
  • Department of Clinical Laboratory Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, 200072 China.
  • Department of Food Science and Biotechnology and Institute for Basic Sciences, Sungshin Women's University, Seoul, 01133 Republic of Korea.

Abstract

This study aimed to evaluate the effects of Korean Sajabal mugwort extract (SME), green tea extract (GTE), and their optimized combination on improving blood flow. We first found that SME and GTE significantly suppressed TNF-α-induced ICAM-1 expression and enhanced endothelial nitric oxide synthase (eNOS) activation in EA.hy926 endothelial cells. Based on synergistic effects on regulation of IκBα, the mixture of SME and GTE at 9:1 ratio was determined as the optimal combination, and it also suppressed integrin LFA-1 expression, reducing leukocyte-endothelial cell interactions. The major components of SME (eupatilin and jaceosidin) and GTE (EGCG) were quantified, and their effects were consistent with the extracts. Furthermore, the mixture alleviated pulmonary vein occlusion, and decreased mRNA levels of ICAM-1, VCAM-1, P-selectin, and E-selectin in aortic tissue in collagen/epinephrine-induced thrombosis rat model. Taken together, the SME and GTE mixture effectively improved blow flow and may be a potent agent for preventing thrombosis and atherosclerosis.

MeSH

Cells, Tea, Blood, Endothelial Cells, Thrombosis, Blood Circulation, Selectins