Journal Article Review Epublish
PubMed: 40160356 DOI: 10.1039/d4sc08495k
Metal-based immunogenic cell death inducers for cancer immunotherapy.
Chem Sci 16(15):6160-6187
Authors: Jiao Xia Zou, Meng Rui Chang, Nikita A Kuznetsov, Jia Xuan Kee, Maria V Babak, Wee Han Ang
Affiliations
- Department of Chemistry, National University of Singapore 4 Science Drive 2 Singapore 117544 Singapore.
- Drug Discovery Lab, Department of Chemistry, City University of Hong Kong 83 Tat Chee Avenue Hong Kong SAR 999077 People's Republic of China.
- NUS Graduate School - Integrative Science and Engineering Programme (ISEP), National University of Singapore 21 Lower Kent Ridge Rd Singapore 119077 Singapore.
Abstract
Immunogenic cell death (ICD) has attracted enormous attention over the past decade due to its unique characteristics in cancer cell death and its role in activating innate and adaptive immune responses against tumours. Many efforts have been dedicated to screening, identifying and discovering ICD inducers, resulting in the validation of several based on metal complexes. In this review, we provide a comprehensive summary of current metal-based ICD inducers, their molecular mechanisms for triggering ICD initiation and subsequent protective antitumour immune responses, along with considerations for validating ICD both and . We also aim to offer insights into the future development of metal complexes with enhanced ICD-inducing properties and their applications in potentiating antitumour immunity.
MeSH
Cells, Neoplasms, Immunogenic Cell Death, Immunotherapy, Coordination Complexes, Immunity, Cell Death