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Publications

Journal Article Review Ppublish

PubMed: 40190622 DOI: 10.1293/tox.2024-0071

Comparative anatomy of respiratory bronchioles and lobular structures in mammals.

J Toxicol Pathol 38(2):113-129

Authors: Yumi Umeda, Takeshi Izawa, Kei Kazama, Sachiko Arai, Junichi Kamiie, Shinichiro Nakamura, Kazuki Hano, Masaki Takasu, Akihiro Hirata, Susanne Rittinghausen, Shotaro Yamano

Affiliations

  • National Institute of Occupational Safety and Health, Japan, Organization of Occupational Health and Safety, 2-26-1 Muraoka-higashi, Fujisawa, Kanagawa 251-0015, Japan.
  • Laboratory of Veterinary Pathology, Osaka Metropolitan University Graduate School of Veterinary Science, 1-58 Rinku-Orai-Kita, Izumisano, Osaka 598-8531, Japan.
  • Department of Veterinary Medicine, Azabu University, School of Veterinary Medicine, 17-71 Fuchinobe 1-chome, Chuo-ku, Sagamihara 252-5201, Japan.
  • Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.
  • Laboratory of Laboratory Animal Science, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.
  • Gifu University Institute for Advanced Study, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
  • Center for One Medicine Innovative Translational Research (COMIT), Gifu University, 1-1 Yanagido, Gifu, 501-1193, Gifu, 501-1193, Japan.
  • Laboratory of Veterinary Pathology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
  • Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Nikolai-Fuchs-Strasse 1, 30625, Hannover, Germany.

Abstract

Rodents are widely used to study the toxicity of chemicals; however, differences between species indicate that the results from rodents are not always directly transferable to humans. The health of workers exposed to various chemicals and particulates at high doses or for long periods is at risk. Respiratory bronchioles and lobular structures, which are demarcated by interlobular septa, are key sites for occupational lung diseases such as pneumoconiosis; however, these structures vary among animal species. Understanding these differences is crucial for studying the pathology of human occupational lung diseases. However, there is a lack of reviews focusing on these structures in different species. This review explores the lung anatomy of various mammals and its functional importance in disease to connect animal studies with human occupational lung diseases. Our results indicate that artiodactyls, especially small pig breeds and goats, are ideal for research because their respiratory bronchioles and lobular structures are similar to those of humans. This review aims to enhance the use of experimental animal data and improve our understanding of human occupational lung diseases, thereby facilitating early disease detection, treatment, and prevention.

MeSH

Bronchioles, Anatomy, Comparative, Lung, Lung Diseases, Anatomy