Journal Article Epublish 1 citation
PubMed: 40195183 DOI: 10.1186/s41824-025-00247-7
Medium-vessel vasculitis following COVID-19 moderna (mRNA-1273) vaccination and the utility of PET-CT as a diagnostic tool: a case report.
EJNMMI Rep 9(1):12
Authors: Martin H Cherk, Luigi Zolio, Sadid Khan, Sharmayne Brady
Affiliations
- Department of Nuclear Medicine & PET Alfred Hospital, Melbourne, Australia.
- Monash University, Melbourne, Australia.
- Department of Rheumatology Alfred Hospital, Melbourne, Australia.
- University of Melbourne, Melbourne, Australia.
- Department of Infectious Diseases Alfred Hospital, Melbourne, Australia.
- Monash University, Melbourne, Australia.
Abstract
There have been several case reports of COVID-19 "BNT162b2" (Pfizer-BioNTech) and "mRNA-1273" (Moderna) vaccination associated small and medium vessel vasculitis described in the literature however none have had F-FDG Positron Emission Tomography scans (PET/CT) performed for diagnosis. We report the case of a 57-year-old Caucasian male patient from Australia where F-FDG PET/CT scanning facilitated early detection of a medium-vessel vasculitis following Moderna (mRNA-1273) COVID-19 vaccination. The diagnosis would otherwise have been difficult and allowed exclusion of alternative diagnoses and sparing of more invasive investigations such as muscle biopsy. Our case highlights the development of a medium vessel vasculitis following mRNA based COVID-19 vaccination and demonstrates the utility of F-FDG PET/CT as an excellent non-invasive test for the detection of this serious rare and often difficult to diagnose condition.
MeSH
Vasculitis, Vaccines, Positron-Emission Tomography, Rna, Messenger, Positron Emission Tomography Computed Tomography, Vaccination, Covid-19, Diagnosis