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Publications

Journal Article Epublish

PubMed: 40196074 DOI: 10.7759/cureus.80257

Cutaneous Adverse Events Following COVID-19 Vaccination in Japan: A Questionnaire Survey.

Cureus 17(3):e80257

Authors: Yuto Yamamura, Chisa Nakashima, Nana Kagawa, Yumi Aoyama, Akihisa Yamamoto, Hisao Kawahira, Yumiko Kubota, Saeko Nakajima, Takeshi Nakahara, Yoko Fuyuno, Daisuke Tsuruta, Ayaki Matsumoto, Risa Matsuo, Riichiro Abe, Akihiko Yuki, Hayato Takahashi, Chiaki Takahashi, Shin'Ichi Imafuku, Emi Sato, Susumu Fujiwara, Masahito Yasuda, Yayoi Tada, Kotaro Hayashi, Norito Katoh, Daisuke Watanabe, Atsushi Otsuka

Affiliations

  • Dermatology, Kindai University, Osaka, JPN.
  • Dermatology, Kawasaki Medical School, Kurashiki, JPN.
  • Dermatology, Takarazuka City Hospital, Takarazuka, JPN.
  • Dermatology, Kagoshima University, Kagoshima, JPN.
  • Dermatology, Fukuoka Sanno Hospital, Fukuoka, JPN.
  • Dermatology, Kyoto University Graduate School of Medicine, Kyoto, JPN.
  • Dermatology, Kyushu University, Fukuoka, JPN.
  • Dermatology, Osaka Metropolitan University, Osaka, JPN.
  • Dermatology, Asahikawa Medical University, Asahikawa, JPN.
  • Dermatology, Niigata University, Faculty of Medicine, Graduate School of Medical and Dental Science, Niigata, JPN.
  • Dermatology, Niigata University, Faculty of Medicine, Graduate School of Medical and Dental Sciences, Niigata, JPN.
  • Dermatology, Keio University School of Medicine, Tokyo, JPN.
  • Dermatology, Fukuoka University, Fukuoka, JPN.
  • Dermatology, Kobe University Graduate School of Medicine, Kobe, JPN.
  • Dermatology, Gunma University Graduate School of Medicine, Gunma, JPN.
  • Dermatology, Teikyo University School of Medicine, Tokyo, JPN.
  • Dermatology, North Campus, Kyoto Prefectural University of Medicine, Kyoto, JPN.
  • Dermatology, Aichi Medical University, School of Medicine, Aichi, JPN.

Abstract

We conducted a nationwide survey in Japan to clarify the clinical spectrum of these events. An initial questionnaire was sent to 126 dermatology facilities, and responses were obtained from 66 (52.4%). Among these responding facilities, the most commonly identified cutaneous adverse events after COVID-19 vaccination were urticaria (49 (74.2%)), delayed local reactions (37 (56.1%)), erythema multiforme (31 (47.0%)), and alopecia (30 (45.5%)). In the detailed survey, the primary adverse events were EM (19 (20.9%)), bullous pemphigoid (7 (7.7%)), and alopecia (6 (6.6%)). The mean latency from vaccination to onset was 13.1 days, and the mean duration of symptoms was 74.2 days. Although this study cannot establish a direct causal relationship between vaccination and adverse events, it highlights the need for dermatologists to recognize potential cutaneous reactions and provide appropriate care.

MeSH

Vaccines, Vaccination, Pemphigoid, Bullous, Drug-Related Side Effects And Adverse Reactions, Covid-19, Erythema Multiforme, Psoriasis, Alopecia