Journal Article Review Ppublish
PubMed: 40209111 DOI: 10.1210/endocr/bqaf072
O-GlcNAcylation in Endocrinology: The Sweet Link.
Endocrinology 166(6)
Authors: Adam Salm Knier, Stephanie Olivier-Van Stichelen
Affiliations
- Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA. Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
- Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
- Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Abstract
O-GlcNAcylation is a dynamic posttranslational modification that involves the addition of N-acetylglucosamine (GlcNAc) to the serine and threonine residues of proteins. Over the past 4 decades, this modification has become increasingly recognized as having a critical influence in the field of endocrinology. The carefully controlled hormonal input for regulating sleep, mood, response to stress, growth, development, and metabolism are often associated with O-GlcNAc-dependent signaling. As protein O-GlcNAcylation patterns are heavily dependent on environmental glucose concentrations, hormone-secreting cells sense the changes in local environmental glucose concentrations and adjust hormone secretion accordingly. This ability of cells to sense nutritional cues and fine-tune hormonal production is particularly relevant toward maintaining a functional and responsive endocrine system, therefore emphasizing the importance of O-GlcNAc in the scope and application of endocrinology. This review examines how O-GlcNAcylation participates in hormonal homeostasis in different endocrine tissues and systems, from the pineal gland to the placenta, and underscores the significance of O-GlcNAc in the field of endocrinology.
MeSH
Endocrinology, Cells, Growth, Stress, Physiological, Hormones