Journal Article Epublish
PubMed: 40218250 DOI: 10.3390/diagnostics15070900
A Multicentric Study on Adverse COVID-19 Outcomes Among Pregnant and Nonpregnant Women in Multidisciplinary Hospitals of Kazakhstan.
Diagnostics (Basel) 15(7)
Authors: Zhansaya Nurgaliyeva, Lyudmila Pivina, Sharapat Moiynbayeva, Galiya Alibayeva, Meruyert Suleimenova, Nailya Kozhekenova, Moldir Abdullina, Maulen Malgazhdarov, Mira Turbekova, Dejan Nikolic, Milan Lackovic, Antonio Sarria-Santamera, Milena Santric-Milicevic
Affiliations
- Faculty of Medicine and Health Care, Al-Farabi Kazakh National University, Almaty 050044, Kazakhstan.
- Department of Internal Medicine, Semey Medical University, Semey 071407, Kazakhstan.
- Department of Science and Consulting, Kazakhstan Medical University «KSPH», Almaty 050044, Kazakhstan.
- Semey Emergency Hospital, Semey 071407, Kazakhstan.
- Department of Science, S.D. Asfendiyarov Kazakh National Medical University, Almaty 050044, Kazakhstan.
- Department of Surgical Diseases No. 2, Kazakh-Russian Medical University, Almaty 050044, Kazakhstan. Karasai Interdistrict Multidisciplinary Hospital, Almaty 050044, Kazakhstan.
- Department of Clinical Disciplines, Al-Farabi Kazakh National University, Almaty 050044, Kazakhstan.
- Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
- Department of Physical Medicine and Rehabilitation, University Children's Hospital, 11000 Belgrade, Serbia.
- University Hospital "Dragisa Misovic", 11000 Belgrade, Serbia.
- School of Medicine, Nazarbayev University, Astana 010000, Kazakhstan.
- School of Public Health, Nazarbayev University, Astana 010000, Kazakhstan.
- Laboratory for Strengthening the Health System and Workforce for Health Equity, Institute of Social Medicine, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Abstract
The study aimed at identification and analysis of adverse COVID-19 outcomes (admission to intensive care units due to COVID-19, acute respiratory distress syndrome, mechanical ventilation, and death) among hospitalized pregnant and nonpregnant women, which are critical for informed decision-making in obstetric diagnostics and healthcare. This was a retrospective observational study conducted on a series of inpatient pregnant women comparatively followed up with nonpregnant women hospitalized between 15 July 2020 to 20 January 2022 across multidisciplinary hospitals in three cities of Kazakhstan. Following group matching with propensity score for COVID-19 disease severity, residence status, and age, the study ultimately included 156 participants, of whom 50% were pregnant, from an initial sample of 314 female inpatients diagnosed with COVID-19. All findings were considered statistically significant at a -value < 0.05. Laboratory investigations revealed significantly elevated levels of erythrocyte sedimentation rate, creatinine, neutrophils, platelet count, alanine aminotransferase, aspartate aminotransferase, lymphocyte count, and C-reactive protein in pregnant inpatients compared to nonpregnant inpatients. Furthermore, pregnant women exhibited significantly higher levels of D-dimer (2402.97 ng/mL vs. 793.91 ng/mL) and procalcitonin (0.398 ng/mL vs. 0.134 ng/mL) compared to their nonpregnant counterparts. Overall, 16.88% of the pregnant women were admitted to the intensive care unit, whereas among the nonpregnant women, only 2.6% were hospitalized. The most lethal outcomes (8.3%) occurred among pregnant women, while for nonpregnant women, there were two cases (1.3%). Pregnant women diagnosed with COVID-19 may exhibit more severe clinical symptoms and encounter more adverse outcomes compared to their nonpregnant counterparts. Future research should incorporate larger matched samples to comprehensively explore the association between additional factors and clinical conditions.
MeSH
Pregnant Women, Pregnancy, Aspartate Aminotransferases, Transaminases, Signs And Symptoms, Covid-19, Intensive Care Units