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Publications

Journal Article Review Epublish

PubMed: 40231207 DOI: 10.34133/bmr.0160

The Application of Stem Cells and Exosomes in Promoting Nerve Conduits for Peripheral Nerve Repair.

Biomater Res 29:0160

Authors: Mengen Li, Ye Tang, Chengkai Zhou, Yan Geng, Chenxi Zhang, Yuwei Hsu, Le Ma, Wei Guo, Ming Li, Yanhua Wang

Affiliations

  • National Center for Trauma Medicine, Beijing 100044, China. Key Laboratory of Trauma and Neural Regeneration, Ministry of Education, Peking University, Beijing 100044, China. Trauma Medicine Center, Peking University People's Hospital, Beijing 100044, China. Department of Orthopedics and Trauma, Peking University People's Hospital, Beijing 100044, China.
  • National Center for Trauma Medicine, Beijing 100044, China. Key Laboratory of Trauma and Neural Regeneration, Ministry of Education, Peking University, Beijing 100044, China. Trauma Medicine Center, Peking University People's Hospital, Beijing 100044, China.
  • National Center for Trauma Medicine, Beijing 100044, China. Key Laboratory of Trauma and Neural Regeneration, Ministry of Education, Peking University, Beijing 100044, China. Trauma Medicine Center, Peking University People's Hospital, Beijing 100044, China. Emergency Department, Peking University People's Hospital, Beijing 100044, China.
  • Emergency Department, Peking University People's Hospital, Beijing 100044, China.
  • National Center for Trauma Medicine, Beijing 100044, China. Key Laboratory of Trauma and Neural Regeneration, Ministry of Education, Peking University, Beijing 100044, China. Department of Orthopedics and Trauma, Peking University People's Hospital, Beijing 100044, China.

Abstract

The repair of peripheral nerve injury (PNI) presents a multifaceted and protracted challenge, with current therapeutic approaches failing to achieve optimal repair outcomes, thereby not satisfying the considerable clinical demand. The advent of tissue engineering has led to a growing body of experimental evidence indicating that the synergistic application of nerve conduits, which provide structural guidance, alongside the biological signals derived from exosomes and stem cells, yields superior therapeutic results for PNI compared to isolated interventions. This combined approach holds great promise for clinical application. In this review, we present the latest advancements in the treatment of PNI through the integration of stem cells or exosomes with nerve conduits. We have addressed the inadequate efficiency of exosomes or stem cells in conjunction with nerve conduits from 3 perspectives: enhancing stem cells or exosomes, improving nerve conduits, and incorporating physical stimulation.

MeSH

Cells, Microscopy, Electron, Scanning Transmission, Peripheral Nerves, Stem Cells, Exosomes, Therapeutics