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Publications

Journal Article Review Ppublish 1 citation

PubMed: 40234288 DOI: 10.1007/s12035-025-04846-0

Microbiome Gut-Brain-Axis: Impact on Brain Development and Mental Health.

Mol Neurobiol 62(8):10813-10833

Authors: Yasmin N Ramadan, Saleh F Alqifari, Khaled Alshehri, Amirah Alhowiti, Hyder Mirghani, Tariq Alrasheed, Faisal Aljohani, Abdulaziz Alghamdi, Helal F Hetta

Affiliations

  • Department of Microbiology and Immunology, Faculty of Pharmacy, Assiut University, Assiut, 71515, Egypt.
  • Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, 71491, Tabuk, Saudi Arabia.
  • Department of Internal Medicine (Neurology), Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia.
  • Department of Family and Community Medicine, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia.
  • Department of Internal Medicine, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia.
  • Division of Medicine and Gastroenterology, Department of Medicine, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia.
  • Department of Medicine, Division of Psychiatry, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Division of Microbiology, Immunology and Biotechnology, Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, University of Tabuk, 71491, Tabuk, Saudi Arabia.

Abstract

The current discovery that the gut microbiome, which contains roughly 100 trillion microbes, affects health and disease has catalyzed a boom in multidisciplinary research efforts focused on understanding this relationship. Also, it is commonly demonstrated that the gut and the CNS are closely related in a bidirectional pathway. A balanced gut microbiome is essential for regular brain activities and emotional responses. On the other hand, the CNS regulates the majority of GI physiology. Any disruption in this bidirectional pathway led to a progression of health problems in both directions, neurological and gastrointestinal diseases. In this review, we hope to shed light on the complicated connections of the microbiome-gut-brain axis and the critical roles of gut microbiome in the early development of the brain in order to get a deeper knowledge of microbiome-mediated pathological conditions and management options through rebalancing of gut microbiome.

MeSH

Neurobiology, Brain, Gastrointestinal Microbiome, Mental Health