Journal Article Review Epublish
PubMed: 40243418 DOI: 10.3390/ijms26072828
Role of miRNAs in Bovine Oocyte Maturation and Reproductive Regulation.
Int J Mol Sci 26(7)
Authors: Xiaogeng Yang, Honghong He, Peng Wang, Yaying Wang, Linlin Wang, Falong Yang, Jian Li, Huizhu Zhang
Affiliations
- Key Laboratory of Animal Medicine, Southwest Minzu University of Sichuan Province, Chengdu 610041, China. Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Ministry of Education, Chengdu 610041, China.
- Key Laboratory of Animal Medicine, Southwest Minzu University of Sichuan Province, Chengdu 610041, China.
- Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Ministry of Education, Chengdu 610041, China.
- Animal Husbandry Science Institute of Ganzi Tibetan Autonomous Prefecture, Kangding 626000, China.
- College of Pharmacy and Food, Southwest Minzu University, Chengdu 610041, China.
Abstract
MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs that regulate target gene expression in many eukaryotes. MiRNAs are essential for post-transcriptional regulation, influencing various biological functions, including oocyte growth and maturation, fertilization, early embryo development, and implantation. In recent decades, numerous studies have identified a substantial number of miRNAs associated with mammalian oocyte maturation and early embryo development, utilizing methods such as small RNA sequencing and modulating miRNA expression through overexpression or inhibition. In this review, we introduce the biosynthesis of miRNAs and their regulatory roles in germ cells, summarizing the expression patterns and post-transcriptional regulation of miRNAs during oocyte maturation and early embryo development, as well as their potential application in assisted reproductive technology (ART).
MeSH
Embryonic Development, Micrornas, Oocytes